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Article
Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencing
The tandem PHD finger–bromodomain, found in many chromatin-associated proteins, has an important role in gene silencing by the human co-repressor KRAB-associated protein 1 (KAP1). Here we report the three-dime...
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Chapter
Structure and Function of Protein Modules in Chromatin Biology
Chromatin-mediated gene transcription or silencing is a dynamic process in which binding of various proteins or protein complexes can displace nucleosomal histones from DNA to relieve repression or drive...
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Protocol
Vector Geometry Map**
Members of the EF-hand protein superfamily (1) share a common calciumbinding helix-loop-helix motif as a building block, whose conformation essentially determines biological function. It has been well demonstrate...
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Article
Where cancer meets calcium — p53 crosstalk with EF-hands
S100B, an EF-hand Ca2+-binding protein, grasps the C-terminus of the tumor suppressor p53 and inhibits protein kinase C-dependent phosphorylation and acetylation of p53 in a Ca2+-dependent manner. The mode of int...
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Article
Calmodulin Target Database
The intracellular calcium sensor protein calmodulin (CaM) interacts with a large number of proteins to regulate their biological functions in response to calcium stimulus. This molecular recognition process is...
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Chapter
Calmodulin Target Recognition: Common Mechanism and Structural Diversity
Calmodulin is an intracellular calcium receptor which regulates the biological activities of a wide variety of proteins including protein kinases, phosphatases, and ion transporters. During the past decade, th...
