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Author Correction: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
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Publisher Correction: Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures
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Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures
Cerebrospinal fluid (CSF) proteins and their structures have been implicated in aging and neurodegenerative diseases. In the present study, we used limited proteolysis–mass spectrometry (LiP–MS) to screen for ...
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Article
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing1–3. Cerebrospinal fluid (CSF) makes up the immediate environm...
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Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Physiological blood–brain transport is impaired with age by a shift in transcytosis
The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to maintain brain function in part via its low transcellular permeability1–3. Yet, recent studies have demonstrated that ...
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Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report ...
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CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
Microglia maintain homeostasis in the central nervous system through phagocytic clearance of protein aggregates and cellular debris. This function deteriorates during ageing and neurodegenerative disease, conc...
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The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity
Failure to clear apoptotic cells can lead to autoinflammatory disease. Means and colleagues demonstrate that the receptor SCARF1 recognizes C1q-bound apoptotic cells, which leads to their clearance and prevent...
