Abstract
The dimeric epipolythiodiketopiperazine alkaloids are a family of fungal metabolites renowned for their structural and functional complexity [1]. Isolated across eight genera of fungi, over 40 members of this class of natural products have been discovered since the isolation of their inaugural members, (+)-chaetocin A (2) [2] and (+)-verticillin A [3], in 1970 (Fig. 9.1). As evidenced by the large number of constituents comprising this family, there are many avenues by which each member derives its identity.
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Notes
- 1.
We acknowledge financial support by NIH-NIGMS (GM089732).
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Kim J, Movassaghi M (2010) J Am Chem Soc 132:14376
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Kim, J., Movassaghi, M. (2012). (+)-11,11′-Dideoxyverticillin A. In: Li, J., Corey, E. (eds) Total Synthesis of Natural Products. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34065-9_9
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