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Author Correction: Cryo-EM of the dynamin polymer assembled on lipid membrane
In Figs. 2b and 3d of this Letter, the labels ‘Dynamin 1’ and ‘Overlay’ were inadvertently swapped. This has been corrected online.
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Cryo-EM of the dynamin polymer assembled on lipid membrane
Membrane fission is a fundamental process in the regulation and remodelling of cell membranes. Dynamin, a large GTPase, mediates membrane fission by assembling around, constricting and cleaving the necks of bu...
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Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
Immunization of cows with a recombinant HIV envelope protein leads to the rapid development of potent, broadly neutralizing antibodies against HIV.
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Open AccessPresenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles
Structures of BG505 SOSIP.664 trimer in complex with broadly neutralizing antibodies (bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1. Presentation of trimeric HIV-1 ...
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Open AccessUncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability
The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we inves...
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Open AccessApproaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding
Development of a prophylactic vaccine against hepatitis C virus (HCV) has been hampered by the extraordinary viral diversity and the poor host immune response. Scaffolding, by grafting an epitope onto a hetero...
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Chapter
Molecular Recognition of HIV Glycans by Antibodies
Human immunodeficiency virus 1 (HIV-1) currently infects over 34 million people across the world and remains one of the greatest global public health burdens despite the development of highly active antiretrov...
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Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
Some broadly neutralizing antibodies to HIV-1 recognize glycan-dependent epitopes on gp120. Now X-ray crystallography and EM approaches, along with functional analyses, reveal how one particular antibody (PGT1...
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Chapter
Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses
Structural biology provides a wealth of information about the three-dimensional organization and chemical makeup of proteins. An understanding of atomic-level structure offers enormous potential to design rati...
