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Article
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies
Dementia with Lewy bodies (DLB) represents a huge medical need as it accounts for up to 30% of all dementia cases, and there is no cure available. The underyling spectrum of pathology is complex and creates a ...
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Article
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report ...
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Reference Work Entry In depth
Microglial Dysfunction in Brain Aging and Neurodegeneration
Aging impacts nearly every tissue and function in an organism and presents the primary risk factor for major human diseases, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Th...
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Living Reference Work Entry In depth
Microglial Dysfunction in Brain Aging and Neurodegeneration
Aging impacts nearly every tissue and function in an organism and presents the primary risk factor for major human diseases, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Th...
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Article
Open AccessStructural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug
As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with age-relat...
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Article
The dark side of BrdU in neural stem cell biology: detrimental effects on cell cycle, differentiation and survival
5-Bromo-2′-deoxyuridin (BrdU) is frequently used in anaylsis of neural stem cell biology, in particular to label and to fate-map dividing cells. However, up to now, only a few studies have addressed the questi...