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Article
Open AccessEMBER creates a unified space for independent breast cancer transcriptomic datasets enabling precision oncology
Transcriptomics has revolutionized biomedical research and refined breast cancer subty** and diagnostics. However, wider use in clinical practice is hampered for a number of reasons including the application...
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Article
Open AccessRapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program
Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 ...
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Article
Open AccessTGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatenin...
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Article
Open AccessEpithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence
More than 70% of human breast cancers (BCs) are estrogen receptor α-positive (ER+). A clinical challenge of ER+ BC is that they can recur decades after initial treatments. Mechanisms governing latent disease rema...
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Article
Open AccessRNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, su...
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Article
Open AccessADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels
The small intestinal villus tip is the first point of contact for lumen-derived substances including nutrients and microbial products. Electron microscopy studies from the early 1970s uncovered unusual spatial...
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Article
Open AccessEstrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor
Estrogen and progesterone receptor (ER, PR) signaling control breast development and im**e on breast carcinogenesis. ER is an established driver of ER + disease but the role of the PR, itself an ER target ge...
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Article
Open AccessDeep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features
Patient-Derived Xenografts (PDXs) are the preclinical models which best recapitulate inter- and intra-patient complexity of human breast malignancies, and are also emerging as useful tools to study the normal ...
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Article
Open AccessA novel culture method that sustains ERα signaling in human breast cancer tissue microstructures
Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) ...
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Article
Open AccessThe secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix,...
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Article
Open AccessOestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
Oestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset o...
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Analysis of Mammary Gland Phenotypes by Transplantation of the Genetically Marked Mammary Epithelium
The mammary gland is the only organ to undergo most of its development after birth and therefore particularly attractive for studying developmental processes. In the mouse, powerful tissue recombination techni...
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Breast Cancer Microenvironment and the Metastatic Process
Metastases are the main cause of breast cancer-related death: hence, the clinical need to prevent and to stop metastasis is of outmost importance. Evidence has accumulated that the propensity of breast cancer ...
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Article
Patient-derived xenograft (PDX) models in basic and translational breast cancer research
Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical re...
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Article
Correction: Corrigendum: Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
Nat. Cell Biol. 17, 1193–1204 (2015); published online 24 August 2015; corrected after print 28 August 2015 An error in the print version of this Article meant that Witold W. Kilarski's name was incorrect. Thi...
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Article
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of th...
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Reply to Is progesterone a neutral or protective factor for breast cancer?
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Article
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight
Mutations are not always sufficient to drive breast carcinogenesis but additional factors determine whether genetically altered cells progress to the state dur...
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Article
Does Cancer Start in the Womb? Altered Mammary Gland Development and Predisposition to Breast Cancer due to in Utero Exposure to Endocrine Disruptors
We are now witnessing a resurgence of theories of development and carcinogenesis in which the environment is again being accepted as a major player in phenotype determination. Perturbations in the fetal enviro...
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Article
ER and PR signaling nodes during mammary gland development
The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (E...
