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Open AccessRAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells
Breast cancer stem cells (BCSC) are presumed to be responsible for treatment resistance, tumor recurrence and metastasis of breast tumors. However, development of BCSC-targeting therapies has been held back by...
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Article
Open AccessMicroenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
Dissemination of tumour cells to the bone marrow is an early event in breast cancer, however cells may lie dormant for many years before bone metastases develop. Treatment for bone metastases is not curative, ...
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Article
Open AccessThe Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells
This review will discuss how the steroid hormones, estrogen and progesterone, as well as treatments that target steroid receptors, can regulate cancer stem cell (CSC) activity. The CSC theory proposes a hierar...
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Article
Erratum: Interrogating open issues in cancer medicine with patient-derived xenografts
Nature Reviews Cancer 17, 254–268 (2017) In the online html version of this article, Joan Seoane's affiliations were not correct. He is also a member of the EurOPDX Consortium and is at the Vall d'Hebron Insti...
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Article
Interrogating open issues in cancer precision medicine with patient-derived xenografts
This Opinion article discusses progress and challenges in using patient-derived xenograft (PDX) models in cancer precision medicine. It is primarily co-authored by members of the EurOPDX Consortium and as such...
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Erratum to: Patient-Derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis
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Patient-derived xenograft (PDX) models in basic and translational breast cancer research
Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical re...
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Article
Open AccessPatient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis
Breast cancer specific mortality results from tumour cell dissemination and metastatic colonisation. Identification of the cells and processes responsible for metastasis will enable better prevention and contr...
