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Article
Open AccessRapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program
Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 ...
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Article
Open AccessTranscriptomic characterization of the histopathological growth patterns in breast cancer liver metastases
Metastatic breast cancer (mBC) remains incurable and liver metastases (LM) are observed in approximately 50% of all patients with mBC. In some cases, surgical resection of breast cancer liver metastases (BCLM)...
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Article
Open AccessHistopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases
Liver is the third most common organ for breast cancer (BC) metastasis. Two main histopathological growth patterns (HGP) exist in liver metastases (LM): desmoplastic and replacement. Although a reduced immunot...
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Article
Open AccessObesity-associated changes in molecular biology of primary breast cancer
Obesity is associated with an increased risk of develo** breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the bi...
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Article
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling
Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation; however, some nutrients available at distant organs may inherently promote metastatic growth. We find that the lung an...
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Article
Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights
The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, have further su...
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Article
Open AccessSingle cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast
Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) from 9 BC patients and compar...
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Article
Open AccessThe association between adiposity and anti-proliferative response to neoadjuvant endocrine therapy with letrozole in post-menopausal patients with estrogen receptor positive breast cancer
The impact of adiposity on the efficacy of endocrine treatment in patients with estrogen receptor positive breast cancer is poorly investigated. Here, we retrospectively investigated in a cohort of 56 patients...
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Tumor Infiltrating Lymphocytes in Breast Cancer: Implementation of a New Histopathological Biomarker
In this chapter we describe a promising new histopathological biomarker in immuno-pathology/oncology: tumor infiltrating lymphocytes (TILs). The semiquantitative assessment of TILs in breast cancer (and other ...
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Article
Open AccessAssociation between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of live...
