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Article
Open AccessRNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, su...
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Article
Open AccessEstrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor
Estrogen and progesterone receptor (ER, PR) signaling control breast development and im**e on breast carcinogenesis. ER is an established driver of ER + disease but the role of the PR, itself an ER target ge...
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Article
Open AccessOestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
Oestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset o...
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Article
Prolactin signaling and Stat5: going their own separate ways?
Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by studying PrlR-...
