25 Result(s)

Article

Improving laboratory animal genetic reporting: LAG-R guidelines

The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized re...

Lydia Teboul, James Amos-Landgraf, Fernando J. Benavides… in Nature Communications (2024)

Article

Development of two mouse strains conditionally expressing bright luciferases with distinct emission spectra as new tools for in vivo imaging

In vivo bioluminescence imaging (BLI) has been an invaluable noninvasive method to visualize molecular and cellular behaviors in laboratory animals. Bioluminescent reporter mice harboring luciferases for gener...

Toshiaki Nakashiba, Katsunori Ogoh, Satoshi Iwano, Takashi Sugiyama… in Lab Animal (2023)

Article

Genetic quality: a complex issue for experimental study reproducibility

Laboratory animal research involving mice, requires consideration of many factors to be controlled. Genetic quality is one factor that is often overlooked but is essential for the generation of reproducible ex...

Atsushi Yoshiki, Gregory Ballard, Ana V. Perez in Transgenic Research (2022)

Article

Mouse resources at the RIKEN BioResource Research Center and the National BioResource Project core facility in Japan

The RIKEN BioResource Research Center (BRC) was established in 2001 as a comprehensive biological resource center in Japan. The Experimental Animal Division, one of the BRC infrastructure divisions, has been d...

Saori Mizuno-Iijima, Toshiaki Nakashiba, Shinya Ayabe, Hatsumi Nakata… in Mammalian Genome (2022)

Article

MoG+: a database of genomic variations across three mouse subspecies for biomedical research

Laboratory mouse strains have mosaic genomes derived from at least three major subspecies that are distributed in Eurasia. Here, we describe genomic variations in ten inbred strains: Mus musculus musculus-derived...

Toyoyuki Takada, Kentaro Fukuta, Daiki Usuda, Tatsuya Kushida… in Mammalian Genome (2022)

Article

Asian Mouse Mutagenesis Resource Association (AMMRA): mouse genetics and laboratory animal resources in the Asia Pacific

The Asian Mouse Mutagenesis Resource Association (AMMRA) is a non-profit organization consisting of major resource and research institutions with rodent expertise from within the Asia Pacific region. For more ...

Hsian-Jean Chin, Michael S. Dobbie, **ang Gao, James E. Hennessy… in Mammalian Genome (2022)

Article

Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros… in Genome Biology (2021)

Article

Establishment and application of information resource of mutant mice in RIKEN BioResource Research Center

Online databases are crucial infrastructures to facilitate the wide effective and efficient use of mouse mutant resources in life sciences. The number and types of mouse resources have been rapidly growing due...

Hiroshi Masuya, Daiki Usuda, Hatsumi Nakata, Naomi Yuhara… in Laboratory Animal Research (2021)

Article

Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis

F1 hybrid progenies between related subspecies often show hybrid sterility (HS) or inviability. HS is caused by failure of meiotic chromosome synapsis and sex body formation in house mouse. Previous studies id...

Kento Morimoto, Koki Numata, Yoko Daitoku, Yuko Hamada… in Scientific Reports (2020)

Article

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

Pogo transposable element derived with ZNF domain (POGZ) has been identified as one of the most recurrently de novo mutated genes in patients with neurodevelopmental disorders (NDDs), including autism spectrum di...

Kensuke Matsumura, Kaoru Seiriki, Shota Okada, Masashi Nagase… in Nature Communications (2020)

Article

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study re...

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros… in Genome Biology (2019)

Article

Correction: Corrigendum: High-throughput discovery of novel developmental phenotypes

Nature 537, 508–514 (2016); doi:10.1038/nature19356 In this Article, the author Wolfgang Wurst was erroneously omitted from the author list. They are associated with the affiliations: HelmholtzZentrum Munich, ...

Mary E. Dickinson, Ann M. Flenniken, **ao Ji, Lydia Teboul, Michael D. Wong… in Nature (2017)

Article

Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice

Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder and major depression. Several previous studies reported th...

Yosefu Arime, Ryutaro Fukumura, Ikuo Miura… in Behavioral and Brain Functions (2014)

Article

Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: Identification as an allele of 'Hyp'

The endopeptidase encoded by Phex (phosphate-regulating gene with homologies to endopeptidases linked to the X chromosome) is critical for regulation of bone matrix mineralization and phosphate homeostasis. PHEX ...

Kenji Moriyama, Atsuko Hanai, Kazuyuki Mekada… in Journal of Biomedical Science (2011)