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Article
Open AccessGood death for people living with dementia: a qualitative study
Ensuring a good death is one of the primary objectives of palliative care and end-of-life care. There is insufficient evidence regarding what defines a good death for people living with dementia. Obtaining an ...
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Article
Open AccessA case report of a prolonged decrease in tacrolimus clearance due to co-administration of nirmatrelvir/ritonavir in a lung transplant recipient receiving itraconazole prophylaxis
Drug-drug interaction management is complex. Nirmatrelvir/ritonavir is a potent cytochrome P450 (CYP) 3A inhibitor and influences pharmacokinetics of co-administered drugs. Although there are several reports a...
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Article
Open AccessPhysical performance reference values for Japanese oldest old: a SONIC study
The oldest old, defined as those aged 90 or over, is now the fastest-growing population sector. This study aimed to determine reference values for several physical performance measures (PPMs) among 90-year-old...
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Article
Open AccessAssociation of personality traits with polypharmacy among community-dwelling older adults in Japan: a cross-sectional analysis of data from the SONIC study
Polypharmacy is a serious concern among older adults and is frequently related to adverse outcomes, including health problems, reduced quality of life, and increased medical expenses. Although personality trai...
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Article
Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors
Recent studies revealed that colorectal tumors are composed of genetically diverse subclones. We aimed to clarify whether the surface microstructures of colorectal tumors are associated with genetic intratumor...
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Article
Subtypes of the Type II Pit Pattern Reflect Distinct Molecular Subclasses in the Serrated Neoplastic Pathway
Colorectal serrated lesions (SLs) are important premalignant lesions whose clinical and biological features are not fully understood.
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Article
Assessing competence at a higher level among older adults: development of the Japan Science and Technology Agency Index of Competence (JST-IC)
Older adults’ ever-improving health and changing lifestyles necessitate the development of a scale that can better measure their competence at a higher level. We developed the Japan Science and Technology Agen...
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Article
Open AccessCirculating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis
MicroRNAs (miRNAs) are involved in the regulation of key biological processes and have been implicated in various diseases, including autoimmune disorders. The pathogenesis of polymyositis (PM) and dermatomyos...
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Chapter and Conference Paper
Development of Manufacturing Techniques by Hand for Non-straight Braids
Using a Marudai and hand braiding methodology, with repetitive thread movement patterns and bobbin positioning, different curved (curvature radius) braids were created. While the conventional straight braid wa...
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Article
Anatomical variations of liver blood supply in patients with pancreaticobiliary maljunction
Pancreaticobiliary maljunction (PBM) arises from a developmental abnormality during the embryonic period; thus, these patients may have anatomical variations of the liver blood supply, including aberrant vesse...
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Article
Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats
The mechanisms for diet-induced intramyocellular lipid accumulation and its association with insulin resistance remain contentious. In a detailed time-course study in rats, we examined whether a high-fat diet ...
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Article
Preoperative Bile Replacement Improves Immune Function for Jaundiced Patients Treated with External Biliary Drainage
Although preoperative biliary drainage in jaundiced patients is controversial, external biliary drainage (EBD) is beneficial for infection control in patients with biliary cancers. When EBD is performed, addit...
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Article
Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case
A 25-year-old woman was referred to our hospital with persistent upper abdominal pain. Preoperative imaging studies revealed a hilar bile duct stricture with portal venous encasement, and the patient underwent...
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Chapter and Conference Paper
Development of Linked Open Data for Bioresources
The broad dissemination of information is a key issue in improving access to existing bioresources. We attempted to develop Linked Open Data (LOD) for bioresources available at the RIKEN BioResource Center. Th...
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Article
Significance of trough monitoring for tacrolimus blood concentration and calcineurin activity in adult patients undergoing primary living-donor liver transplantation
Tacrolimus pharmacokinetics and calcineurin activity in peripheral blood mononuclear cells (PBMCs) were investigated in adult patients undergoing primary living-donor liver transplantation (LDLT) in order to c...
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Article
Noninvasive positive pressure ventilation in patients with perioperative negative pressure pulmonary edema
Negative pressure pulmonary edema (NPPE) is a noncardiogenic pathological process that is treated with invasive ventilation via a tracheal tube. To investigate the feasibility and safety of noninvasive positiv...
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Article
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly
Lissencephaly is a developmental brain disorder caused by mutations in LIS1 and characterized by impaired neuronal migration. Inhibiting calpain prevents LIS1 degradation in heterozygous mice and rescues the defe...
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Article
Factors predicting successful noninvasive ventilation in acute lung injury
Noninvasive ventilation (NIV) has been successfully used to treat various forms of acute respiratory failure. It remains unclear whether NIV has potential as an effective therapeutic method in patients with ac...
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Article
Clinical role and efficacy of landiolol in the intensive care unit
Beta-adrenergic receptor blockers have proved to be effective for the management of various cardiovascular diseases and the prevention of perioperative cardiac events and cerebrovascular accidents. Landiolol i...
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Article
Empathizing and Systemizing in Adults with and without Autism Spectrum Conditions: Cross-Cultural Stability
This study tests the empathizing-systemizing (E-S) theory of sex differences and the extreme male brain (EMB) theory of autism. Three groups of participants took part: n = 48 people with autism spectrum, n = 137 ...
