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Article
Open AccessSecretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches
Cancer cells inevitably interact with neighboring host tissue-resident cells during the process of metastatic colonization, establishing a metastatic niche to fuel their survival, growth, and invasion. However...
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Article
Open AccessDevelopment of two mouse strains conditionally expressing bright luciferases with distinct emission spectra as new tools for in vivo imaging
In vivo bioluminescence imaging (BLI) has been an invaluable noninvasive method to visualize molecular and cellular behaviors in laboratory animals. Bioluminescent reporter mice harboring luciferases for gener...
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Article
Open AccessA non-invasive system to monitor in vivo neural graft activity after spinal cord injury
Expectations for neural stem/progenitor cell (NS/PC) transplantation as a treatment for spinal cord injury (SCI) are increasing. However, whether and how grafted cells are incorporated into the host neural cir...
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Article
Open AccessA luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
In preclinical cancer research, bioluminescence imaging with firefly luciferase and D-luciferin has become a standard to monitor biological processes both in vitro and in vivo. However, the emission maximum (λmax
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Article
Spectroscopic studies of the color modulation mechanism of firefly (beetle) bioluminescence with amino-analogs of luciferin and oxyluciferin
Spectroscopic properties of amino-analogs of luciferin and oxyluciferin were investigated to confirm the color modulation mechanism of firefly (beetle) bioluminescence. Fluorescence solvatochromic character of...
