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Open AccessAn old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development
The BTBR T+Itpr3tf/J (BTBR/J) strain is one of the most valid models of idiopathic autism, serving as a potent forward genetics tool to dissect the complexity of autism. We found that a sister strain with an inta...
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Article
Open AccessSex-linked markers in an Australian frog Platyplectrum ornatum (Limnodynastidae) with a small genome and homomorphic sex chromosomes
Amphibians have highly diverse sex-determining modes leading to a notable interest in vertebrate sex determination and sex chromosome evolution. The identification of sex-determining systems in amphibians, how...
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Article
Biopsy remains indispensable for evaluating bone marrow involvement in DLBCL patients despite the use of positron emission tomography
Initial staging by positron emission tomography/computed tomography (PET/CT) scanning is recommended for patients with diffuse large B-cell lymphoma (DLBCL). Whether both PET/CT and bone marrow biopsy (BMB) ar...
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Article
Publisher Correction: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity
A contribution of epigenetic modifications to B cell tolerance has been proposed but not directly tested. Here we report that deficiency of ten–eleven translocation (Tet) DNA demethylase family members Tet2 an...
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Article
Light-chain plasma cell myeloma caused by 14q32/IGH translocation and loss of the other allele
Light-chain plasma cell myeloma (LC-PCM) is a PCM subtype in which only immunoglobulin light-chain is secreted. However, the absence of immunoglobulin heavy-chain (IGH) production in this condition has not bee...
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Article
Open AccessA rapid rate of sex-chromosome turnover and non-random transitions in true frogs
The canonical model of sex-chromosome evolution predicts that, as recombination is suppressed along sex chromosomes, gametologs will progressively differentiate, eventually becoming heteromorphic. However, the...
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Article
Correction to: Cell dynamics during differentiation therapy with all-trans retinoic acid in acute promyelocytic leukemia
In the original publication of the article, Table 2 was published incorrectly. The column names were swapped under the column heading “Prom (%)”. The correct column names are PB and BM.
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Article
Open AccessGenetic map** of a male factor subfertility locus on mouse chromosome 4
Male reproductive anomalies are widely distributed among mammals, and male factors are estimated to contribute to approximately 50% of cases of human infertility. The B10.M/Sgn (B10.M) mouse strain exhibits tw...
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Article
Open AccessA portion of expanded granular lymphocytes cause pure white cell aplasia?
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Cell dynamics during differentiation therapy with all-trans retinoic acid in acute promyelocytic leukemia
The introduction of all-trans retinoic acid (ATRA) has made acute promyelocytic leukemia (APL) a curable disease; however, early death prior to the completion of treatment remains a problem. In quantitative evalu...
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Article
Open AccessDe novo acute lymphoblastic leukemia-like disease of high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a case report and literature review
B-cell lymphomas harboring the 8q24/MYC plus 18q21/BCL2 translocations are now referred to as high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-MBR). Although HGBL-MBR is frequently fo...
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Article
Open AccessThe parathyroid hormone regulates skin tumour susceptibility in mice
Using a forward genetics approach to map loci in a mouse skin cancer model, we previously identified a genetic locus, Skin tumour modifier of MSM 1 (Stmm1) on chromosome 7, conferring strong tumour resistance. Su...
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Article
Open AccessPhylogeography reveals an ancient cryptic radiation in East-Asian tree frogs (Hyla japonica group) and complex relationships between continental and island lineages
In contrast to the Western Palearctic and Nearctic biogeographic regions, the phylogeography of Eastern-Palearctic terrestrial vertebrates has received relatively little attention. In East Asia, tectonic event...
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Article
Forward-genetics analysis of sleep in randomly mutagenized mice
Sleep is conserved from invertebrates to vertebrates, and is tightly regulated in a homeostatic manner. The molecular and cellular mechanisms that determine the amount of rapid eye movement sleep (REMS) and no...
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Article
Open AccessIdentification of mutations through dominant screening for obesity using C57BL/6 substrains
The discovery of leptin substantiated the usefulness of a forward genetic approach in elucidating the molecular network regulating energy metabolism. However, no successful dominant screening for obesity has b...
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Article
STAP cells are derived from ES cells
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Article
Open AccessKDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR
KDEL receptors are responsible for retrotransporting endoplasmic reticulum (ER) chaperones from the Golgi complex to the ER. Here we describe a role for KDEL receptor 1 (KDELR1) that involves the regulation of...
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Article
A Cascade of epistatic interactions regulating teratozoospermia in mice
Infertility in humans and subfertility in domestic animals are two major reproductive problems. Among human couples, ~15 % are diagnosed as infertile, and males are considered responsible in about 50 % of the ...
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Article
PAX5-positive plasma cell myeloma with t(9;14;11)(p13;q32;q13), a novel complex variant translocation of t(11;14)(q13;q32) and t(9;14)(p13;q32)
We describe herein the case of a 64-year-old man with a diagnosis of plasma cell myeloma (PCM). A chromosome analysis based on G-banding and spectral karyoty** revealed the following complex karyotype: 46,XY...
