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Article
Open AccessGenetic quality: a complex issue for experimental study reproducibility
Laboratory animal research involving mice, requires consideration of many factors to be controlled. Genetic quality is one factor that is often overlooked but is essential for the generation of reproducible ex...
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Article
Open AccessMild reproductive impact of a Y chromosome deletion on a C57BL/6J substrain
A recently reported deletion of about 40 Mb in length between 6.12/6.57 and 46.73/47.31 Mb on the Y chromosome long arm of the C57BL/6JBomTac inbred strain made us closely examine the strain’s breeding history...
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Article
Open AccessThe case for genetic monitoring of mice and rats used in biomedical research
Currently, there is the potential to generate over 200,000 mutant mouse strains between existing mouse strains (over 24,000) and genetically modified mouse embryonic stem cells (over 209,000) that have been en...
