17 Result(s)
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Article
Philippe Pierre
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Article
Open AccessDEPDC5 protects CD8+ T cells from ferroptosis by limiting mTORC1-mediated purine catabolism
Peripheral CD8+ T cell number is tightly controlled but the precise molecular mechanism regulating this process is still not fully understood. In this study, we found that epilepsy patients with loss of function ...
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Open AccessRUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes
Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing p...
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Open AccessDistinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells
Cellular metabolism underpins immune cell functionality, yet our understanding of metabolic influences in human dendritic cell biology and their ability to orchestrate immune responses is poorly developed. Her...
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Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-1...
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Open AccessTime trend of clinical cases of Lyme disease in two hospitals in Belgium, 2000–2013
As several studies indicated an increase in Lyme disease (LD), notably in neighbouring countries, concerns have arisen regarding the evolution of Lyme disease in Belgium. In order to confirm or infirm the incr...
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Open AccessBAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
Toll-like receptors (TLR) are essential components of the innate immune system. Several accessory proteins, such as UNC93B1, are required for transport and activation of nucleic acid sensing Toll-like receptor...
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Open AccessMRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced ...
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Open AccessGCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism
It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid ava...
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Loss of translation: a stealth weapon against pathogens?
Various receptors alert cells to microbial invasion through the detection of conserved molecular patterns and initiate innate immunity. During infection with Legionella pneumophila, macrophages modulate cytokine ...
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Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
Phosphorylation of the eukaryotic initiation factor 2 α subunit (eIF2α) is increased in the brains of Alzheimer's disease patients and model mice. Here the authors show that knocking down two kinases that phos...
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Exaggerated translation causes synaptic and behavioural aberrations associated with autism
Mice overexpressing eIF4E show autism-related behaviours and altered synaptic activity in the hippocampus, prefrontal cortex and striatum, and these phenotypes can be rescued with the cap-dependent translation...
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Open AccessDC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells
The advent of Systems Biology has been accompanied by the blooming of pathway databases. Currently pathways are defined generically with respect to the organ or cell type where a reaction takes place. The cell...
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Open AccessRibosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS
Dendritic cells (DCs) are the sentinels of the mammalian immune system, characterized by a complex maturation process driven by pathogen detection. Although multiple studies have described the analysis of acti...
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SUnSET, a nonradioactive method to monitor protein synthesis
As an alternative to the use of radioactively labeled amino acids, incorporation of puromycin into proteins allows evaluation of translation in heterogenous cell populations by flow cytometry analysis after st...
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Open AccessNovel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling
Dendritic cells (DCs) are a complex group of cells that play a critical role in vertebrate immunity. Lymph-node resident DCs (LN-DCs) are subdivided into conventional DC (cDC) subsets (CD11b and CD8α in mouse;...
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Transient aggregation of ubiquitinated proteins during dendritic cell maturation
Dendritic cells (DCs) are antigen-presenting cells with the unique capacity to initiate primary immune responses1. Dendritic cells have a remarkable pattern of differentiation (maturation) that exhibits highly sp...
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Developmental regulation of MHC class II transport in mouse dendritic cells
Dendritic cells (DCs) have the unique capacity to initiate primary and secondary immune responses1,2,3. They acquire antigens in peripheral tissues and migrate to lymphoid organs where they present processed pept...
