-
Article
Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) has been shown to activate the eIF2α kinase PERK to directly regulate translation initiation. Tight control of PERK-eIF2α signaling has...
-
Article
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
Mice overexpressing eIF4E show autism-related behaviours and altered synaptic activity in the hippocampus, prefrontal cortex and striatum, and these phenotypes can be rescued with the cap-dependent translation...
-
Protocol
Translational Regulation of Synaptic Plasticity
Synaptic plasticity defines the process by which synapses, the connections between neurons, can be modified in response to activity. Plasticity can be either positive or negative, with strengthening and weaken...
-
Article
Haloperidol Regulates the State of Phosphorylation of Ribosomal Protein S6 via Activation of PKA and Phosphorylation of DARPP-32
Administration of typical antipsychotic drugs, such as haloperidol, promotes cAMP-dependent signaling in the medium spiny neurons (MSNs) of the striatum. In this study, we have examined the effect of haloperid...
