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  1. Article

    Open Access

    RUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes

    Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing p...

    Rémy Char, Zhuangzhuang Liu, Cédric Jacqueline, Marion Davieau in Nature Communications (2023)

  2. Article

    Open Access

    BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

    Toll-like receptors (TLR) are essential components of the innate immune system. Several accessory proteins, such as UNC93B1, are required for transport and activation of nucleic acid sensing Toll-like receptor...

    Alexis Combes, Voahirana Camosseto, Prudence N’Guessan in Nature Communications (2017)

  3. No Access

    Article

    Transient aggregation of ubiquitinated proteins during dendritic cell maturation

    Dendritic cells (DCs) are antigen-presenting cells with the unique capacity to initiate primary immune responses1. Dendritic cells have a remarkable pattern of differentiation (maturation) that exhibits highly sp...

    Hugues Lelouard, Evelina Gatti, Fanny Cappello, Olivia Gresser in Nature (2002)