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Article
Open AccessRUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes
Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing p...
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Article
Open AccessBAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
Toll-like receptors (TLR) are essential components of the innate immune system. Several accessory proteins, such as UNC93B1, are required for transport and activation of nucleic acid sensing Toll-like receptor...
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Article
Transient aggregation of ubiquitinated proteins during dendritic cell maturation
Dendritic cells (DCs) are antigen-presenting cells with the unique capacity to initiate primary immune responses1. Dendritic cells have a remarkable pattern of differentiation (maturation) that exhibits highly sp...