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Article
Open AccessTwo opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour
The decision to either approach or avoid a potentially threatening environment is thought to rely upon the coordinated activity of heterogeneous neural populations in the hippocampus and prefrontal cortex (PFC...
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Article
Cocaine exposure reorganizes cell type– and input-specific connectivity in the nucleus accumbens
Repeated cocaine exposure enhances excitatory connections onto medium spiny neurons (MSNs) in the nucleus accumbens (NAc). The authors show that cocaine selectively increases basolateral amygdala inputs onto d...
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Article
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
Mice overexpressing eIF4E show autism-related behaviours and altered synaptic activity in the hippocampus, prefrontal cortex and striatum, and these phenotypes can be rescued with the cap-dependent translation...
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Article
Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens
The authors report that medium spiny neurons in the mouse nucleus accumbens receive inputs from the cortex, thalamus and hippocampus, but the differential subcellular connectivity of hippocampal inputs makes t...
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Neuronal Mitochondrial Transport and Dysfunction
Neuronal function is dependent on energy provision by mitochondria. It has recently emerged that the precise localization of mitochondria at regions with high energy demands such as the active synapse is requi...
