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Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids
Gene therapy is switched on and off by changes in diet.
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Article
Open AccessGCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism
It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid ava...