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Article
γδ T cells in tissue physiology and surveillance
γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By rapidly producing large amounts of cy...
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Article
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-1...
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Article
Open AccessLymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
Medullary thymic epithelial cells (mTEC) purge the T cell repertoire of autoreactive thymocytes. Although dendritic cells (DC) reinforce this process by transporting innocuous peripheral self-antigens, the mec...
