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Article
Open AccessHCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy
Renal inflammation and fibrosis are the common pathways leading to progressive chronic kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as upregulated in human chronic allograft i...
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Article
Activation of STAT3 signaling pathway in the kidney of COVID-19 patients
Acute kidney injury is common in patients with COVID-19, however mechanisms of kidney injury remain unclear. Since cytokine storm is likely a cause of AKI and glomerular disease, we investigated the two major ...
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Article
Open AccessGlobal transcriptomic changes in glomerular endothelial cells in mice with podocyte depletion and glomerulosclerosis
Podocytes are a key component of the glomerular filtration barrier, and its dysfunction and eventual loss drive glomerular disease progression. Recent research has demonstrated the importance of podocyte cross...
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Article
Open AccessArctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
Arctigenin (ATG) is a major component of Fructus Arctii, a traditional herbal remedy that reduced proteinuria in diabetic patients. However, whether ATG specifically provides renoprotection in DKD is not known. H...
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Article
Open AccessPublisher Correction: Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
Open AccessPublisher Correction: Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
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Article
Open AccessPuerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes
Radix puerariae, a traditional Chinese herbal medication, has been used to treat patients with diabetic nephropathy (DN). Several studies demonstrated that puerarin, the active compound of radix puerariae, reduce...
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Article
Open AccessRtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy
We previously reported a critical role of reticulon (RTN) 1A in mediating endoplasmic reticulum (ER) stress in kidney tubular cells and the expression of RTN1A correlates with the renal function and the severi...
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Article
Open AccessRole of C/EBP-α in Adriamycin-induced podocyte injury
Podocytes are terminally differentiated epithelial cells in the kidney glomeruli that act as a key component of the glomerular filtration barrier. Although the inciting injury to the podocyte may vary between ...
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Article
Open AccessErratum: RTN1 mediates progression of kidney disease by inducing ER stress
Nature Communications 6: Article number: 7841 (2015); Published: 31 July 2015; Updated: 22 October 2015. The original version of the Supplementary Information attached to this Article did not contain Supplemen...
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Article
Open AccessRTN1 mediates progression of kidney disease by inducing ER stress
Identification of new biomarkers and drug targets for chronic kidney disease (CKD) is required for the development of more effective therapy. Here we report an association between expression of reticulon 1 (RT...
