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Article
Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy
We previously demonstrated that ginsenoside Re (G-Re) has protective effects on acute kidney injury. However, the underlying mechanism is still unclear. In this study, we conducted a meta-analysis and pathway ...
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Article
Open AccessHCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy
Renal inflammation and fibrosis are the common pathways leading to progressive chronic kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as upregulated in human chronic allograft i...
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Article
Genetic susceptibility to diabetic kidney disease is linked to promoter variants of XOR
The lifetime risk of kidney disease in people with diabetes is 10–30%, implicating genetic predisposition in the cause of diabetic kidney disease (DKD). Here we identify an expression quantitative trait loci (...
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Article
Open AccessLINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer
Long Interspersed Nuclear Element-1 (LINE-1, L1) is increasingly regarded as a genetic risk for lung cancer. Transcriptionally active LINE-1 forms a L1-gene chimeric transcript (LCTs), through somatic L1 retro...
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Article
Open AccessReversible dysregulation of renal circadian rhythm in lupus nephritis
We have found disruption of expression of major transcriptional regulators of circadian rhythm in the kidneys of several mouse models of lupus nephritis. Here we define the consequence of this disturbance with...
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Article
Open AccessGlobal transcriptomic changes in glomerular endothelial cells in mice with podocyte depletion and glomerulosclerosis
Podocytes are a key component of the glomerular filtration barrier, and its dysfunction and eventual loss drive glomerular disease progression. Recent research has demonstrated the importance of podocyte cross...
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Article
Open AccessPublisher Correction: The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms
HIV-associated nephropathy (HIVAN) is a rapidly progressive kidney disease that is caused by HIV infection of renal epithelial cells with subsequent expression of viral genes, including vpr. Antiretroviral therap...
