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Article
Open AccessHCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy
Renal inflammation and fibrosis are the common pathways leading to progressive chronic kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as upregulated in human chronic allograft i...
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Article
Cellular recovery after prolonged warm ischaemia of the whole body
After cessation of blood flow or similar ischaemic exposures, deleterious molecular cascades commence in mammalian cells, eventually leading to their death1,2. Yet with targeted interventions, these processes can...
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Article
4D flow MRI for the assessment of renal transplant dysfunction: initial results
(1) Determine inter-observer reproducibility and test-retest repeatability of 4D flow parameters in renal allograft vessels; (2) determine if 4D flow measurements in the renal artery (RA) and renal vein (RV) c...
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Article
Open AccessTemporal trends of dialysis requiring acute kidney injury after orthotopic cardiac and liver transplant hospitalizations
The epidemiology and outcomes of acute kidney injury (AKI) in prevalent non-renal solid organ transplant recipients is unknown.
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Article
Open AccessNovel Therapeutics Identification for Fibrosis in Renal Allograft Using Integrative Informatics Approach
Chronic allograft damage, defined by interstitial fibrosis and tubular atrophy (IF/TA), is a leading cause of allograft failure. Few effective therapeutic options are available to prevent the progression of IF...
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Chapter
Cardiac Surveillance Whilst Listed for Renal Transplantation
The renal transplant waiting list in the United States has almost doubled since 2002 [1]. Annual mortality whilst listed is estimated at 5% [2], a third of cases with a documented cause are attributable to cardio...
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Article
The management of hyponatremia in HIV disease
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Article
Molecular targets for treatment of kidney fibrosis
Renal fibrosis is the culmination of processes driven by signaling pathways involving transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear factor κB, Wnt/β-catenin, Notch,...
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Article
Hepatitis C virus infection among patients with non-Hodgkin’s lymphoma in northern India
Hepatitis C virus (HCV) has been postulated to be an etiological agent for lymphoid malignancies. Whereas a high prevalence of HCV infection in non-Hodgkin’s lymphoma (NHL) patients has been shown to exist in ...
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Article
Open AccessSuccessful medical management of emphysematous gastritis with concomitant portal venous air: a case report
The causes of diffuse abdominal pain following pelvic surgery are numerous. We present a rare case of acute abdominal pain in a woman in the post-partum period.
