-
Article
Open AccessHCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy
Renal inflammation and fibrosis are the common pathways leading to progressive chronic kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as upregulated in human chronic allograft i...
-
Article
Open AccessProteomic characterization of acute kidney injury in patients hospitalized with SARS-CoV2 infection
Acute kidney injury (AKI) is a known complication of COVID-19 and is associated with an increased risk of in-hospital mortality. Unbiased proteomics using biological specimens can lead to improved risk stratif...
-
Article
Activation of STAT3 signaling pathway in the kidney of COVID-19 patients
Acute kidney injury is common in patients with COVID-19, however mechanisms of kidney injury remain unclear. Since cytokine storm is likely a cause of AKI and glomerular disease, we investigated the two major ...
-
Article
Publisher Correction: A systems approach identifies HIPK2 as a key regulator of kidney fibrosis
-
Article
Open AccessGlobal transcriptomic changes in glomerular endothelial cells in mice with podocyte depletion and glomerulosclerosis
Podocytes are a key component of the glomerular filtration barrier, and its dysfunction and eventual loss drive glomerular disease progression. Recent research has demonstrated the importance of podocyte cross...
-
Article
Open AccessArctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
Arctigenin (ATG) is a major component of Fructus Arctii, a traditional herbal remedy that reduced proteinuria in diabetic patients. However, whether ATG specifically provides renoprotection in DKD is not known. H...
-
Article
Open AccessPublisher Correction: Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
-
Article
Open AccessPublisher Correction: Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
-
Article
Open AccessPuerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes
Radix puerariae, a traditional Chinese herbal medication, has been used to treat patients with diabetic nephropathy (DN). Several studies demonstrated that puerarin, the active compound of radix puerariae, reduce...
-
Article
Open AccessLncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma
Long non-coding RNA HOTAIR was regarded as an oncogene in multiple cancers. Previous studies have shown that HOTAIR is involved in the proliferation and tumorigenesis of renal carcinoma cells, wh...
-
Article
Open AccessRtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy
We previously reported a critical role of reticulon (RTN) 1A in mediating endoplasmic reticulum (ER) stress in kidney tubular cells and the expression of RTN1A correlates with the renal function and the severi...
-
Article
The Role of Endoplasmic Reticulum Stress in Diabetic Nephropathy
Diabetic nephropathy (DN) has become the leading cause of end-stage renal disease (ESRD) worldwide. Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a major role in the development a...
-
Article
Open AccessNovel Therapeutics Identification for Fibrosis in Renal Allograft Using Integrative Informatics Approach
Chronic allograft damage, defined by interstitial fibrosis and tubular atrophy (IF/TA), is a leading cause of allograft failure. Few effective therapeutic options are available to prevent the progression of IF...
-
Article
Open AccessRole of C/EBP-α in Adriamycin-induced podocyte injury
Podocytes are terminally differentiated epithelial cells in the kidney glomeruli that act as a key component of the glomerular filtration barrier. Although the inciting injury to the podocyte may vary between ...
-
Article
Open AccessAn update: the role of Nephrin inside and outside the kidney
Nephrin is a key molecule in podocytes to maintain normal slit diaphragm structure. Nephin interacts with many other podocyte and slit diaphragm protein and also mediates important cell signaling pathways in p...
-
Article
Open AccessMyeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization
Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages. eNOS and nNOS mutant mice show comparabl...
-
Article
A systems approach identifies HIPK2 as a key regulator of kidney fibrosis
HIV infection is often associated with severe nephropathy, including renal fibrosis. John He and his colleagues have used a systems biology approach in a mouse model of HIV infection to identify the key factor...
-
Article
Open AccessTranscription factor IRF8 directs a silencing programme for TH17 cell differentiation
TH17 cells are recognized as a unique subset of T helper cells that have critical roles in the pathogenesis of autoimmunity and tissue inflammation. Although RORγt is necessary for the generation of TH17 cells, t...
