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Article
Genetic susceptibility to diabetic kidney disease is linked to promoter variants of XOR
The lifetime risk of kidney disease in people with diabetes is 10–30%, implicating genetic predisposition in the cause of diabetic kidney disease (DKD). Here we identify an expression quantitative trait loci (...
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Article
Open AccessCOL4A4 variant recently identified: lessons learned in variant interpretation—a case report
Alport syndrome is a hereditary kidney disease characterized by hematuria and proteinuria. Although there have been reports of autosomal dominant COL4A4 variants, this is likely an underdiagnosed condition. Impro...
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Article
Activation of STAT3 signaling pathway in the kidney of COVID-19 patients
Acute kidney injury is common in patients with COVID-19, however mechanisms of kidney injury remain unclear. Since cytokine storm is likely a cause of AKI and glomerular disease, we investigated the two major ...
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Article
4D flow MRI for the assessment of renal transplant dysfunction: initial results
(1) Determine inter-observer reproducibility and test-retest repeatability of 4D flow parameters in renal allograft vessels; (2) determine if 4D flow measurements in the renal artery (RA) and renal vein (RV) c...
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Article
Open AccessDisruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI) treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System, that dasatinib is associa...
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Chapter and Conference Paper
Open Governance in Authoritarian States: A Framework for Assessing Digital Participation in the Age of Mass Surveillance
With the growing utilization of “smart” technologies, social media and “Internet of Things” applications, citizen-government interactions are rapidly changing. These changes have substantially transformed part...
