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Article
Open AccessExtracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and tr...
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Article
Open AccessNanotechnology-enabled immunoengineering approaches to advance therapeutic applications
Immunotherapy has reached clinical success in the last decade, with the emergence of new and effective treatments such as checkpoint blockade therapy and CAR T-cell therapy that have drastically improved patie...
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Article
Static and Dynamic Strength Analysis of Reduction Gears for an Automotive Shift-by-wire Actuator
This paper deals with the static, impact, and dynamic strength of reduction gears applied to a shift-by-wire (SBW) actuator system. A sintered material (FD-0405-60) was used for cost competitiveness and mass p...
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Article
Recurrent feature-incorporated convolutional neural network for virtual metrology of the chemical mechanical planarization process
In semiconductor manufacturing, the chemical mechanical planarization (CMP) process produces higher thickness variability in the edge area of the wafer than that in the center area due to the characteristics o...
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Article
Automatic inspection of salt-and-pepper defects in OLED panels using image processing and control chart techniques
In the manufacture of flat display panels, salt-and-pepper defects are caused by a malfunction in the chemical process. The defects are characterized by the dispersion of many black and white pixels in the dis...
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Article
Characterization of airborne particle release from nanotechnology-enabled clothing products
This study investigated airborne particle release from 17 nanotechnology-enabled clothing items, including 10 items that were advertised as containing silver nanoparticles and 1 item with silver materials. Clo...
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Article
Open AccessGeneration of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening
Even though in vitro co-culture tumor spheroid model plays an important role in screening drug candidates, its wide applications are currently limited due to the lack of reliable and high throughput methods for g...
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Article
Open AccessA biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
Stem cell transplantation, as a promising treatment for central nervous system (CNS) diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete differentiation, and limited neur...
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Article
Open AccessMultidimensional nanomaterials for the control of stem cell fate
Current stem cell therapy suffers low efficiency in giving rise to differentiated cell lineages, which can replace the original damaged cells. Nanomaterials, on the other hand, provide unique physical size, su...
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Article
Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway
Cyclophilin A binds a proline motif in human CrkII, preventing phosphorylation by Abl and EGFR. Decreased CrkII phosphorylation ensures interactions with the focal adhesion proteins paxillin and p130CAS to sti...
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Article
Open AccessNanotopography-mediated Reverse Uptake for siRNA Delivery into Neural Stem Cells to Enhance Neuronal Differentiation
RNA interference (RNAi) for controlling gene expression levels using siRNA or miRNA is emerging as an important tool in stem cell biology. However, the conventional methods used to deliver siRNA into stem cell...
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Article
Open AccessIncorporation of functionalized gold nanoparticles into nanofibers for enhanced attachment and differentiation of mammalian cells
Electrospun nanofibers have been widely used as substrata for mammalian cell culture owing to their structural similarity to natural extracellular matrices. Structurally consistent electrospun nanofibers can b...
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Article
Integrated microfluidic devices for combinatorial cell-based assays
The development of miniaturized cell culture platforms for performing parallel cultures and combinatorial assays is important in cell biology from the single-cell level to the system level. In this paper we de...
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Article
Desmoplastic fibroma of the skull in an infant
A 1-year-old girl presented with a 10-month history of progressive protuberance of the left frontal skull. Magnetic resonance imaging and computed tomography demonstrated a large osteolytic interosseous mass e...
