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Fabrication of Thick and Anisotropic Cardiac Tissue on Nanofibrous Substrate for Repairing Infarcted Myocardium
In this chapter, we introduce the method for fabricating thick and anisotropic cardiac tissue for heart regeneration. Aligned and biodegradable nanofiber can be prepared by electrospinning Food and Drug Admini...
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Article
Open AccessCirculating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring
Directed differentiation methods allow acquisition of high-purity cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs); however, their immaturity characteristic limits their applica...
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Article
Open AccessImpact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials. One pr...
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Open AccessTwo dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system
Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery. As human pluripotent stem cell-derived cardiomyocytes re...
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Article
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
Allogenic induced pluripotent stem cell-derived cardiomyocytes transplanted directly into infarcted cynomolgus monkey hearts show electrical coupling with host cardiomyocytes improve cardiac contractile functi...
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Multidisciplinary research of human pluripotent stem cells for application to cell therapy and drug discovery
We are recently develo** novel technologies for large-scale production of high-quality human pluripotent stem cells (hPSCs) by development of defined and robust adhesion molecules for hPSCs as well as other ...
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Open AccessIncorporation of functionalized gold nanoparticles into nanofibers for enhanced attachment and differentiation of mammalian cells
Electrospun nanofibers have been widely used as substrata for mammalian cell culture owing to their structural similarity to natural extracellular matrices. Structurally consistent electrospun nanofibers can b...
