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  1. No Access

    Article

    Enhancing the sensitivity of multidimensional NMR experiments by using triply-compensated π pulses

    In multidimensional solution NMR experiments, π pulses are used extensively for inversion and refocusing operations on 1H, 13C and 15N nuclei. Pulse miscalibration, off-resonance effects, and J-coupling evolution...

    Youlin **a, Paolo Rossi, Manu V. Subrahmanian… in Journal of Biomolecular NMR (2017)

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    Article

    Automatic methyl assignment in large proteins by the MAGIC algorithm

    Selective methyl labeling is an extremely powerful approach to study the structure, dynamics and function of biomolecules by NMR. Despite spectacular progress in the field, such studies remain rather limited i...

    Yoan R. Monneau, Paolo Rossi, Anusarka Bhaumik… in Journal of Biomolecular NMR (2017)

  3. No Access

    Article

    Atomic view of the energy landscape in the allosteric regulation of Abl kinase

    NMR spectroscopy analyses of the Abl regulatory module (RM), which tunes Abl kinase activity, explain the mechanism of certain RM-located drug-resistance mutations.

    Tamjeed Saleh, Paolo Rossi… in Nature Structural & Molecular Biology (2017)

  4. No Access

    Article

    Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

    Cyclophilin A binds a proline motif in human CrkII, preventing phosphorylation by Abl and EGFR. Decreased CrkII phosphorylation ensures interactions with the focal adhesion proteins paxillin and p130CAS to sti...

    Tamjeed Saleh, Wojciech Jankowski, Ganapathy Sriram, Paolo Rossi… in Nature Chemical Biology (2016)

  5. No Access

    Article

    Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII

    NMR structures of CrkL, an adaptor protein that mediates Bcr-Abl signaling in CML, reveal domain organization distinct from CrkII that allows constitutive interaction between CrkL and Abl kinase.

    Wojciech Jankowski, Tamjeed Saleh, Ming-Tao Pai… in Nature Chemical Biology (2012)

  6. No Access

    Article

    Structural basis for regulation of the Crk signaling protein by a proline switch

    Structural analysis by NMR reveals that the Gly237-Pro238 bond of the signaling protein Crk in the cis form stabilizes an autoinhibited conformation between two tandem SH3 domains, whereas the trans form promotes...

    Paramita Sarkar, Tamjeed Saleh, Shiou-Ru Tzeng, Raymond B Birge… in Nature Chemical Biology (2011)