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  1. Article

    Open Access

    Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

    In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. Here, we describe the concept of augmented synthetic lethality (ASL)...

    Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou… in Nature Communications (2020)

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    Article

    Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

    Cyclophilin A binds a proline motif in human CrkII, preventing phosphorylation by Abl and EGFR. Decreased CrkII phosphorylation ensures interactions with the focal adhesion proteins paxillin and p130CAS to sti...

    Tamjeed Saleh, Wojciech Jankowski, Ganapathy Sriram, Paolo Rossi… in Nature Chemical Biology (2016)

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    Article

    Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII

    NMR structures of CrkL, an adaptor protein that mediates Bcr-Abl signaling in CML, reveal domain organization distinct from CrkII that allows constitutive interaction between CrkL and Abl kinase.

    Wojciech Jankowski, Tamjeed Saleh, Ming-Tao Pai… in Nature Chemical Biology (2012)