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Article
Open AccessIncreased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers
Abnormal expression of activating/inhibitory receptors leads to natural killer (NK) cells dysfunction in tumor. Here we show that programmed cell death protein 1 (PD-1), a well-known immune checkpoint of T cel...
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Article
Effects of paclobutrazol on cultivars of Chinese bayberry (Myrica rubra) under salinity stress
Salt stress is one of the most critical factors hindering the growth and development of plants. Paclobutrazol (PBZ) is widely used to minimize this problem in agriculture because it can induce salt stress tole...
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Article
Open AccessThe BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair
The BDNF Val66Met polymorphism has been associated with sensitivity to stress and affective disorders. We therefore sought to model the inter-causality of these relationships under controlled laboratory condit...
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Article
Fine-scale genetic structure due to adaptive divergence among microhabitats
It has been suggested that adaptive evolution on ecological timescales shapes communities. However, adaptation among environments relies on isolation or large selection coefficients that exceed migration effec...
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Article
Proteomic modulation in breast tumors after metformin exposure: results from a “window of opportunity” trial
Reverse Phase Protein Array (RPPA) is a high-throughput antibody-based technique to assess cellular protein activity. The goal of this study was to assess protein marker changes by RPPA in tumor tissue from a ...
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Article
The Potential of Gonadal Hormone Signalling Pathways as Therapeutics for Dementia
Dementia is an ever-expanding problem facing an ageing society. Currently, there is a sharp paucity of treatment strategies. It has long been known that sex hormones, namely 17β-estradiol and testosterone, pos...
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Article
Prevalence and associated factors of myopia among primary and middle school-aged students: a school-based study in Guangzhou
To estimate the prevalence of myopia among primary and middle school-aged students in Guangzhou and to explore the potentially contributing factors to myopia.
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Article
Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism
Major depressive disorder (MDD) is the result of complex gene–environment interactions. According to the World Health Organization, MDD is the leading cause of disability worldwide, and it is a major contribut...
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Article
Open AccessEfficacy, safety and pharmacokinetics of clofarabine in Chinese pediatric patients with refractory or relapsed acute lymphoblastic leukemia: a phase II, multi-center study
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Article
Open AccessPrognostic significance of Versican expression in gastric adenocarcinoma
Gastric cancer (GC) is the leading malignancy in the digestive system. Versican is a ubiquitous component of the extracellular matrix and has a role in tumor progression. We aim to examine the expression of Ve...
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Article
A new 2D cobalt(II) coordination polymer constructed from 1,2,4,5-benzenetetracarboxylate and flexible bis(benzimidazole) ligands
A new 2D cobalt(II) coordination polymers namely {[Co2(btec)(L)2]∙4H2O} n (1), where btec = 1,2,4,5-benzenetetracarboxylate and L = 1,3-bis(5,6-dimethylbenzimidazol-l-yl)-2-prop...
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Article
HbA1c levels as predictors of ablation outcome in type 2 diabetes mellitus and paroxysmal atrial fibrillation
The aim of this study was to evaluate whether the levels of HbA1c could predict the outcome of ablation in patients with type 2 diabetes mellitus (T2DM) and paroxysmal atrial fibrillation (PAF).
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Article
Chronically Recurrent and Widespread Tinea Corporis Due to Trichophyton rubrum in an Immunocompetent Patient
A 31-year-old immunocompetent male who presented with a 4-year history of extensive erythematous and scaly plaques involving the abdomen, gluteal and inguen regions with concomitant tinea pedis and onychomycos...
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Article
Open AccessAlterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation
We investigated in vivo neurochemical markers reflective of neuronal health and glial activation to determine if these could yield clues regarding the reduced fractional anisotropy (FA) of white matter and accele...
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Article
Open AccessAnalyzing the influence of BDNF heterozygosity on spatial memory response to 17β-estradiol
The recent use of estrogen-based therapies as adjunctive treatments for the cognitive impairments of schizophrenia has produced promising results; however the mechanism behind estrogen-based cognitive enhancem...
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Article
Crystal structural and fluorescence properties of a two-dimensional cobaltous coordination polymer containing bis(benzimidazole) ligand
A new 2D coordination polymer {[Co(IPA)(L)]·0.25H2O} n (L = 1,4-bis(5,6-dimethyl-benzimidazolyl)-2-butene, H2IPA = 5-hydroxyisophthalic acid) is hydrothermally synthesized and c...
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Article
Crystal structure, thermal and fluorescent properties of a 1D Cd(II) coordination polymer based on the bis(benzimidazole) ligand
A 1D cadmium (II) coordination polymer {[Cd2(L)3Cl3]·Cl} n (1) (L = 1,3-bis(benzimidazol-l-yl)-2-propanol) is synthesized by the hydrothermal reaction and characterized by eleme...
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Article
Crystal structure and fluorescent properties of a 2D cadmium coordination polymer
A new 2D cadmium(II) coordination polymer {[Cd(MBD)(L)]·(H2O)2} n (1) (H2MBD = 5-methoxycarbonyl-benzene-1,3-dicarboxylic acid, L = 1,3-bis(benzimidazol-l-yl)-2-propanol) is syn...
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Article
Open AccessDry reforming of methane over ZrO2-supported Co–Mo carbide catalyst
The process of dry reforming of methane has the potential to be an effective route for CO2 utilization via syn-gas production. In the present study, ZrO2-supported Co–Mo bimetallic carbide catalysts were prepared...
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Article
Long-term outcome of HLA-haploidentical hematopoietic SCT without in vitro T-cell depletion for adult severe aplastic anemia after modified conditioning and supportive therapy
HLA-haploidentical hematopoietic SCT (HSCT) is an option for severe aplastic anemia (SAA) patients. Here, we evaluated the outcomes of 26 adult-SAA patients who received HLA-haploidentical HSCT in five transpl...
