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  1. No Access

    Article

    Pre-surgical trial of the AKT inhibitor MK-2206 in patients with operable invasive breast cancer: a New York Cancer Consortium trial

    The PI3K/AKT/mTOR pathway is an oncogenic driver in breast cancer (BC). In this multi-center, pre-surgical study, we evaluated the tissue effects of the AKT inhibitor MK-2206 in women with stage I–III BC.

    K. Kalinsky, J. A. Sparano, X. Zhong… in Clinical and Translational Oncology (2018)

  2. No Access

    Article

    Proteomic modulation in breast tumors after metformin exposure: results from a “window of opportunity” trial

    Reverse Phase Protein Array (RPPA) is a high-throughput antibody-based technique to assess cellular protein activity. The goal of this study was to assess protein marker changes by RPPA in tumor tissue from a ...

    K. Kalinsky, T. Zheng, H. Hibshoosh, X. Du, P. Mundi… in Clinical and Translational Oncology (2017)