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  1. No Access

    Article

    Pre-surgical trial of the AKT inhibitor MK-2206 in patients with operable invasive breast cancer: a New York Cancer Consortium trial

    The PI3K/AKT/mTOR pathway is an oncogenic driver in breast cancer (BC). In this multi-center, pre-surgical study, we evaluated the tissue effects of the AKT inhibitor MK-2206 in women with stage I–III BC.

    K. Kalinsky, J. A. Sparano, X. Zhong… in Clinical and Translational Oncology (2018)

  2. No Access

    Article

    Proteomic modulation in breast tumors after metformin exposure: results from a “window of opportunity” trial

    Reverse Phase Protein Array (RPPA) is a high-throughput antibody-based technique to assess cellular protein activity. The goal of this study was to assess protein marker changes by RPPA in tumor tissue from a ...

    K. Kalinsky, T. Zheng, H. Hibshoosh, X. Du, P. Mundi… in Clinical and Translational Oncology (2017)

  3. Article

    Open Access

    Reproductive risk factors and oestrogen/progesterone receptor-negative breast cancer in the Breast Cancer Family Registry

    Oestrogen receptor (ER)- and progesterone receptor (PR)-negative (ER−PR−) breast cancer is associated with poorer prognosis compared with other breast cancer subtypes. High parity has been associated with an i...

    M E Work, E M John, I L Andrulis, J A Knight, Y Liao… in British Journal of Cancer (2014)

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  4. No Access

    Article

    PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer

    Carcinoma is an altered state of tissue differentiation in which epithelial cells no longer respond to cues that keep them in their proper position. A break down in these cues has disastrous consequences not o...

    J S Yu, S Koujak, S Nagase, C-M Li, T Su, X Wang, M Keniry, L Memeo, A Rojtman… in Oncogene (2008)

  5. No Access

    Article

    Incidence and clinical significance of lymph node metastasis detected by imuno-histochemical stain in DCIS

    M. B. El-Tamer, J. Chun, M. Gill, D. Bassi, S. Lee… in Annals of Surgical Oncology (2004)