8 Result(s)

Article

Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array

The Illumina HumanMethylation450 BeadChip (HM450K) measures the DNA methylation of 485,512 CpGs in the human genome. The technology relies on hybridization of genomic fragments to probes on the chip. However, ...

Haroon Naeem, Nicholas C Wong, Zac Chatterton, Matthew K H Hong… in BMC Genomics (2014)

Article

Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1

Acute Myeloid Leukaemia (AML) is a highly heterogeneous disease. Studies in adult AML have identified epigenetic changes, specifically DNA methylation, associated with leukaemia subtype, age of onset and patie...

Leah Morenos, Zac Chatterton, Jane L Ng, Minhee S Halemba… in Molecular Cancer (2014)

Article

Paediatric leukaemia DNA methylation profiling using MBD enrichment and SOLiD sequencing on archival bone marrow smears

Acute Lymphoblastic Leukaemia (ALL) is the most common cancer in children. Over the past four decades, research has advanced the treatment of this cancer from a less than 60% chance of survival to over 85% tod...

Nicholas CL Wong, Gavin D Meredith, George Marnellos, Miroslav Dudas… in GigaScience (2015)

Article

In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the develo** fetal brain

Intrauterine exposure to maternal smoking is linked to impaired executive function and behavioral problems in the offspring. Maternal smoking is associated with reduced fetal brain growth and smaller volume of...

Zac Chatterton, Brigham J. Hartley, Man-Ho Seok… in Epigenetics & Chromatin (2017)

Article

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis

The ERK signalling pathway regulates key cell fate decisions in the intestinal epithelium and is frequently dysregulated in colorectal cancers (CRCs). Variations in the dynamics of ERK activation can induce di...

Lars Tögel, Rebecca Nightingale, Rui Wu, Anderly C. Chüeh… in Scientific Reports (2018)

Article

Single-cell DNA methylation sequencing by combinatorial indexing and enzymatic DNA methylation conversion

DNA methylation is a critical molecular mark involved in cellular differentiation and cell-specific processes. Single-cell whole genome DNA methylation profiling methods hold great potential to resolve the DNA...

Zac Chatterton, Praves Lamichhane, Diba Ahmadi Rastegar… in Cell & Bioscience (2023)

Article

Author Correction: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis

Lars Tögel, Rebecca Nightingale, Rui Wu, Anderly C. Chüeh… in Scientific Reports (2023)

Article

A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells

Parkinson´s disease (PD) is a common neurodegenerative movement disorder and leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for disease intervention. However, the ability to stratify pa...

Yahaira Naaldijk, Belén Fernández, Rachel Fasiczka, Elena Fdez… in npj Parkinson's Disease (2024)