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Article
Open AccessThousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ...
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Article
Reprogramming roadmap reveals route to human induced trophoblast stem cells
The reprogramming of human somatic cells to primed or naive induced pluripotent stem cells recapitulates the stages of early embryonic development1–6. The molecular mechanism that underpins these reprogramming pr...
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Article
Open AccessA urinary microRNA signature can predict the presence of bladder urothelial carcinoma in patients undergoing surveillance
The objective of this study was to determine whether microRNA (miRNA) profiling of urine could identify the presence of urothelial carcinoma of the bladder (UCB) and to compare its performance characteristics ...
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Article
Open AccessTracking the origins and drivers of subclonal metastatic expansion in prostate cancer
Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. He...
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Article
Open AccessReducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array
The Illumina HumanMethylation450 BeadChip (HM450K) measures the DNA methylation of 485,512 CpGs in the human genome. The technology relies on hybridization of genomic fragments to probes on the chip. However, ...
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Reference Work Entry In depth
Non-coding RNA Databases
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Article
Open AccessmiRSel: Automated extraction of associations between microRNAs and genes from the biomedical literature
MicroRNAs have been discovered as important regulators of gene expression. To identify the target genes of microRNAs, several databases and prediction algorithms have been developed. Only few experimentally co...
