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Article
MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer
Recent publications have shown patients with defects in the DNA mismatch repair (MMR) pathway driven by either MSH2 or MSH6 loss experience a significant increase in the incidence of prostate cancer. Moreover,...
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Article
Open AccessComparing nodal versus bony metastatic spread using tumour phylogenies
The role of lymph node metastases in distant prostate cancer dissemination and lethality is ill defined. Patients with metastases restricted to lymph nodes have a better prognosis than those with distant metas...
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Article
Open AccessTracking the origins and drivers of subclonal metastatic expansion in prostate cancer
Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. He...
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Article
Percutaneous image-guided biopsy of prostate cancer metastases yields samples suitable for genomics and personalised oncology
Personalised oncology through mutational profiling of cancers requires the procurement of fresh frozen tumour samples for genomics applications. While primary cancers are often surgically excised and therefore...
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Article
Open AccessReducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array
The Illumina HumanMethylation450 BeadChip (HM450K) measures the DNA methylation of 485,512 CpGs in the human genome. The technology relies on hybridization of genomic fragments to probes on the chip. However, ...
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Article
Outcomes after concurrent inguinal hernia repair and robotic-assisted radical prostatectomy
Inguinal hernias occur more frequently following radical prostatectomy. Simultaneous inguinal hernia repair during open and laparoscopic radical prostatectomy for prostate cancer has been described previously....
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Article
Is the testis intraperitoneal?
The relationship of the testis to the peritoneal cavity, and hence its position as an intraperitoneal or extraperitoneal organ, remains controversial. Adult anatomy texts favour an extraperitoneal position dur...
