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Article
Open AccessA potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells
Parkinson´s disease (PD) is a common neurodegenerative movement disorder and leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for disease intervention. However, the ability to stratify pa...
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Article
Open AccessIron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB
Increased brain iron content has been consistently reported in sporadic Parkinson’s disease (PD) patients, and an increase in cytosolic free iron is known to cause oxidative stress and cell death. However, whe...
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Article
Open AccessParkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
Mutations in LRRK2 are a common genetic cause of Parkinson’s disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various centr...
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Article
Vesicle pools and synapsins: New insights into old enigmas
Synapsins are a multigene family of neuron-specific phosphoproteins and comprise the most abundant synaptic vesicle proteins. They have been proposed to tether synaptic vesicles to each other to maintain a res...
