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Article
Open AccessNeural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy
PACS1 syndrome is a neurodevelopmental disorder (NDD) caused by a recurrent de novo missense mutation in PACS1 (p.Arg203Trp (PACS1R203W)). The mechanism by which PACS1R203W causes PACS1 syndrome is unknown, and n...
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Article
Sleep-mediated regulation of reward circuits: implications in substance use disorders
Our modern society suffers from both pervasive sleep loss and substance abuse—what may be the indications for sleep on substance use disorders (SUDs), and could sleep contribute to the individual variations in...
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Article
Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens
Cocaine craving, seeking, and relapse are mediated, in part, by cocaine-induced adaptive changes in the brain reward circuits. The nucleus accumbens (NAc) integrates and prioritizes different emotional and mot...
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Article
Cocaine-induced neural adaptations in the lateral hypothalamic melanin-concentrating hormone neurons and the role in regulating rapid eye movement sleep after withdrawal
Sleep abnormalities are often a prominent contributor to withdrawal symptoms following chronic drug use. Notably, rapid eye movement (REM) sleep regulates emotional memory, and persistent REM sleep impairment ...
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Article
Chronic sleep fragmentation enhances habenula cholinergic neural activity
Sleep is essential to emotional health. Sleep disturbance, particularly REM sleep disturbance, profoundly impacts emotion regulation, but the underlying neural mechanisms remain elusive. Here we show that chro...
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Article
Silent synapses dictate cocaine memory destabilization and reconsolidation
Cocaine-associated memories are persistent, but, on retrieval, become temporarily destabilized and vulnerable to disruptions, followed by reconsolidation. To explore the synaptic underpinnings for these memory...
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Article
NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward
The diurnal regulation of dopamine is important for normal physiology and diseases such as addiction. Here we find a novel role for the CLOCK protein to antagonize CREB-mediated transcriptional activity at the...
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Article
Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens Projection
Exposure to cocaine induces addiction-associated behaviors partially through remodeling neurocircuits in the nucleus accumbens (NAc). The paraventricular nucleus of thalamus (PVT), which projects to the NAc mo...
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Article
Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses
Cocaine and morphine produce similar addiction-related behaviors, but different adaptations at accumbens synapses. The authors explain this paradox, showing that both drugs generate silent synapses in distinct...
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Article
Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving
In rats self-administering cocaine, drug seeking behavior induced by a cocaine-paired cue increases progressively during cocaine withdrawal. The authors detected silent synapses in basolateral amygdala–to–nucl...
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Article
Cocaine-Induced Membrane Adaptation in the Central Nucleus of Amygdala
Exposure to drugs of abuse lead to both rewarding effects and the subsequent development of negative affects. The progressive dysregulation of both processes is thought to critically contribute to the addictiv...
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Article
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
The β-lactam antibiotics — penicillin and its semisynthetic derivatives — act by inhibiting bacterial synthetic pathways, and their success has in part been because they have little effect on their hosts. So i...