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  1. No Access

    Article

    Anterior cingulate cortex is necessary for spontaneous opioid withdrawal and withdrawal-induced hyperalgesia in male mice

    The anterior cingulate cortex (ACC) is implicated in many pathologies, including depression, anxiety, substance-use disorders, and pain. There is also evidence from brain imaging that the ACC is hyperactive du...

    Dillon S. McDevitt, Greer McKendrick, Nicholas M. Graziane in Neuropsychopharmacology (2021)

  2. No Access

    Article

    Silent synapses dictate cocaine memory destabilization and reconsolidation

    Cocaine-associated memories are persistent, but, on retrieval, become temporarily destabilized and vulnerable to disruptions, followed by reconsolidation. To explore the synaptic underpinnings for these memory...

    William J. Wright, Nicholas M. Graziane, Peter A. Neumann… in Nature Neuroscience (2020)

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    Article

    Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses

    Cocaine and morphine produce similar addiction-related behaviors, but different adaptations at accumbens synapses. The authors explain this paradox, showing that both drugs generate silent synapses in distinct...

    Nicholas M Graziane, Shichao Sun, William J Wright, Daniel Jang… in Nature Neuroscience (2016)

  4. No Access

    Article

    Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving

    In rats self-administering cocaine, drug seeking behavior induced by a cocaine-paired cue increases progressively during cocaine withdrawal. The authors detected silent synapses in basolateral amygdala–to–nucl...

    Brian R Lee, Yao-Ying Ma, Yanhua H Huang, **usong Wang, Mami Otaka… in Nature Neuroscience (2013)