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  1. No Access

    Article

    Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2

    Valproate (VPA) has been used in the treatment of bipolar disorder since the 1990s. However, the therapeutic targets of VPA have remained elusive. Here we employ a preclinical model to identify the therapeutic...

    Ryan W. Logan, Angela R. Ozburn, Rachel N. Arey, Kyle D. Ketchesin… in Molecular Psychiatry (2021)

  2. No Access

    Article

    NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward

    The diurnal regulation of dopamine is important for normal physiology and diseases such as addiction. Here we find a novel role for the CLOCK protein to antagonize CREB-mediated transcriptional activity at the...

    Ryan W. Logan, Puja K. Parekh, Gabrielle N. Kaplan… in Molecular Psychiatry (2019)

  3. Article

    Antimanic Efficacy of a Novel Kv3 Potassium Channel Modulator

    Kv3.1 and Kv3.2 voltage-gated potassium channels are expressed on parvalbumin-positive GABAergic interneurons in corticolimbic brain regions and contribute to high-frequency neural firing. The channels are als...

    Puja K Parekh, Michelle M Sidor, Andrea Gillman… in Neuropsychopharmacology (2018)

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  4. Article

    Open Access

    TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour

    Animals need to sense and react to potentially dangerous environments. TRP ion channels participate in nociception, presumably via Ca2+ influx, in most animal species. However, the relationship between ion permea...

    Amanda S. Lindy, Puja K. Parekh, Richard Zhu, Patrick Kanju… in Nature Communications (2014)

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