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Article
METH exposure alters sperm DNA methylation in F0 mice and mPFC transcriptome in male F1 mice
Methamphetamine (METH) exposure has toxicity in sperm epigenetic phenotype and increases the risk for develo** addiction in their offspring. However, the underlying transgenerational mechanism remains unclear.
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Article
Comparison of dye-based and probe-based RT-LAMP in detection of canine astrovirus
A rapid and sensitive assay is essential for reliable surveillance and diagnosis of canine astrovirus (CaAstV). In this study, two real-time reverse transcription loop-mediated isothermal amplification (RT-LAM...
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Article
Open AccessPaternal methamphetamine exposure induces higher sensitivity to methamphetamine in male offspring through driving ADRB1 on CaMKII-positive neurons in mPFC
Paternal abuse of drugs, such as methamphetamine (METH), elevates the risk of develo** addiction in subsequent generations, however, its underlying molecular mechanism remains poorly understood. Male adult m...
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Article
Open AccessGegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon
Anxiety is a prominent withdrawal symptom of methamphetamine (Meth) addiction. Recently, the gut microbiota has been regarded as a promising target for modulating anxiety. Gegen-Qinlian decoction (GQD) is a cl...
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Article
Chronic sleep fragmentation enhances habenula cholinergic neural activity
Sleep is essential to emotional health. Sleep disturbance, particularly REM sleep disturbance, profoundly impacts emotion regulation, but the underlying neural mechanisms remain elusive. Here we show that chro...
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Article
Open AccessRole of Glutamatergic Projections from the Ventral CA1 to Infralimbic Cortex in Context-Induced Reinstatement of Heroin Seeking
The prelimbic cortex (PL) and infralimbic cortex (IL) play a role in context-induced reinstatement of heroin seeking in an animal model of drug relapse. Both the PL and IL receive direct glutamatergic projecti...
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Article
Open AccessGlutamatergic Projections from the Entorhinal Cortex to Dorsal Dentate Gyrus Mediate Context-Induced Reinstatement of Heroin Seeking
Reexposure to the context associated with heroin intake provokes relapse to drug taking after abstinence. The dorsal dentate gyrus (dDG) and entorhinal cortex (EC) have been implicated in contextual memory pro...
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Article
Genotypic evolution and antigenicity of H9N2 influenza viruses in Shanghai, China
H9N2 influenza viruses have been circulating in China since 1994, but a systematic investigation of H9N2 in Shanghai has not previously been undertaken. Here, using 14 viruses we isolated from poultry and pigs...
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Article
Genetic analysis of H3N2 avian influenza viruses isolated from live poultry markets and poultry slaughterhouses in Shanghai, China in 2013
Five H3N2 avian influenza viruses (AIVs) were isolated from live poultry markets (LPMs) and poultry slaughterhouses in Shanghai, China in 2013. All viruses were characterized by whole-genome sequencing with su...
