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Article
Kidney Function and Cardiovascular Disease: Evidence from Observational Studies and Mendelian Randomization Analyses
Observational studies have identified that declined kidney function was associated with a higher risk of cardiovascular disease (CVD). However, the causation of such associations requires further exploration. ...
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Article
Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets
IgA nephropathy (IgAN) is a genetically complex multifactorial trait. Over the past decade, population-based genome-wide association studies (GWAS) have identified more than 30 IgAN risk loci, providing novel ...
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Article
Hydroxychloroquine reduces proteinuria in Chinese patients with IgA vasculitis nephritis
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Article
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney-biopsy-diagnosed IgAN cases and 28,751...
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Article
Open AccessPrimary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN i...
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Article
Open AccessComparison between hydroxychloroquine and systemic corticosteroids in IgA nephropathy: a two-year follow-up study
Hydroxychloroquine (HCQ) is recommended as a treatment for IgA nephropathy (IgAN) to control proteinuria. The long-term effects of HCQ compared to systemic corticosteroid therapy remain unclear.
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Article
Open AccessPathological and clinical characteristics of late-onset oligomeganephronia based on a histomorphometric study
Late-onset oligomeganephronia (OMN) is a rare chronic kidney disease and has no quantitative criteria for diagnosis yet. The current study aimed to explore its clinicopathological features by histomorphometric...
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Article
A woman with Alport syndrome in compound-heterozygous state in pregnancy: lessons for the clinical nephrologist
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Article
A 16-year-old girl with sudden heart failure and nephrotic syndrome associated with Takayasu’s arteritis
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Article
Open AccessLupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature
Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of varia...
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Article
Shared genetic study gives insights into the shared and distinct pathogenic immunity components of IgA nephropathy and SLE
An autoimmune component has been suggested to play a role in pathogenesis of IgA nephropathy (IgAN). And genetic studies have reported the shared susceptibility loci between IgAN and the prototype autoimmune d...
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Article
Open AccessMetformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway
Evidence suggests that metformin might be a potential candidate for breast cancer treatment. Yet, its relevant molecular mechanisms remain to be fully investigated. We found that metformin could suppress the N...
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Article
Open AccessElevation of erythrocyte sedimentation rate and C-reactive protein levels reflects renal interstitial inflammation in drug-induced acute tubulointerstitial nephritis
A renal biopsy is needed to define active inflammatory infiltration and guide therapeutic management in drug-induced acute tubulointerstitial nephritis (D-ATIN). However, factors such as various contraindicati...
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Article
Open AccessMonoclonal light chain crystalline podocytopathy and tubulopathy associated with monoclonal gammopathy of renal significance: a case report and literature review
Monoclonal gammopathy of renal significance (MGRS) is a recently defined group of renal diseases caused by monoclonal immunoglobulin secreted by nonmalignant proliferative B cell or plasma cell. Monoclonal imm...
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Article
Open AccessPTEN expression is upregulated by a RNA-binding protein RBM38 via enhancing its mRNA stability in breast cancer
PTEN (phosphatase and tensin homolog gene on chromosome 10), a well-characterized tumor suppressor, is a key regulator of the phosphatidylinositol-3-kinase (PI3K)/AKT pathway involved in cell survival, metasta...
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Article
Open AccessRBM38 is involved in TGF-β-induced epithelial-to-mesenchymal transition by stabilising zonula occludens-1 mRNA in breast cancer
The transforming growth factor-β (TGF-β) pathway plays a vital role in driving cancer cell epithelial–mesenchymal transition (EMT). Zonula occludens-1 (ZO-1), which is downregulated in response to TGF-β, is able ...
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Article
Open AccessThe role of c-Myc-RBM38 loop in the growth suppression in breast cancer
RNA-binding protein 38 (RBM38) is a member of the RNA recognition motif (RRM) family of RNA-binding proteins (RBPs). RBM38 often exerts its function by forming regulatory loops with relevant genes. c-Myc is an...
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Article
Open AccessEvaluation of 10 SLE susceptibility loci in Asian populations, which were initially identified in European populations
Ten novel loci have been found to be associated with systemic lupus erythematosus (SLE) susceptibility by a recent genome-wide association study conducted in Europeans. To test their disease associations and g...
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Article
Open AccessNovel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy
Known susceptibility loci together can only explain about 6–8% of the disease heritability of IgA nephropathy (IgAN), suggesting that there are still a large number of genetic variants remained to be discovere...
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Article
High-density genoty** of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
Swapan Nath, Sang-Cheol Bae and colleagues report the results of a large-scale association study of systemic lupus erythematosus in individuals of Asian ancestry. They identify several new susceptibility loci ...
