-
Article
Open AccessPrimary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN i...
-
Article
Open AccessLessons for the clinical nephrologist: a rare case with MGRS characterized by combined crystalline light chain proximal tubulopathy and crystal-storing histiocytosis responding to daratumumab
-
Article
Open AccessPathological and clinical characteristics of late-onset oligomeganephronia based on a histomorphometric study
Late-onset oligomeganephronia (OMN) is a rare chronic kidney disease and has no quantitative criteria for diagnosis yet. The current study aimed to explore its clinicopathological features by histomorphometric...
-
Article
Open AccessA modified renal risk score for Chinese patients with antineutrophil cytoplasmic antibody-associated vasculitis
The renal risk score (RRS) is a useful tool to predict end-stage renal disease (ESRD) in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The current study aimed to validat...
-
Article
A 16-year-old girl with sudden heart failure and nephrotic syndrome associated with Takayasu’s arteritis
-
Article
Pregnancy-associated proliferative glomerulonephritis with monoclonal immunoglobulin deposits
We report a young woman presented with nephrotic syndrome and normotension during every pregnancy and achieved complete remissions after the deliveries. We thus inferred that her nephrotic syndrome was closely...
-
Article
Coexistent light chain deposition disease, light chain cast nephropathy, and vascular light chain amyloidosis in a patient with IgD lambda multiple myeloma
-
Article
A non-invasive differential diagnostic model for light chain cast nephropathy in newly diagnosed multiple myeloma patients with renal involvement: a multicenter study
Light chain cast nephropathy is the most common form of renal lesion in multiple myeloma. Kidney impairment caused by light chain cast nephropathy can be reversed and survival can be improved if early diagnosi...
-
Article
Acute kidney injury associated with thymoma
-
Article
Open AccessMyeloma cast nephropathy with diffuse amyloid casts without systemic amyloidosis: two cases report
Multiple myeloma (MM) is a plasma-cell derived hematologic malignant disease. The malignant proliferating plasma cells secrete massive monoclonal immunoglobulins which lead to various pathologic types of renal...
-
Article
Open AccessElevation of erythrocyte sedimentation rate and C-reactive protein levels reflects renal interstitial inflammation in drug-induced acute tubulointerstitial nephritis
A renal biopsy is needed to define active inflammatory infiltration and guide therapeutic management in drug-induced acute tubulointerstitial nephritis (D-ATIN). However, factors such as various contraindicati...
-
Article
The interesting picture: simultaneous occurrence of myeloma cast nephropathy, light chain deposition disease and light chain proximal tubulopathy in a patient with multiple myeloma
-
Article
Open AccessTy** of hereditary renal amyloidosis presenting with isolated glomerular amyloid deposition
The commonly used methods for amyloid ty** include immunofluorescence or immunohistochemistry (IHC), which sometimes may come with diagnostic pitfalls. Mass spectrometry (MS)-based proteomics has been recogn...
-
Article
Open AccessMonoclonal immunoglobulin mediates complement activation in monoclonal gammopathy associated-C3 glomerulonephritis
C3 glomerulonephritis (C3GN) is a rare disease caused by inherited or acquired complement alternative pathway (CAP) dysregulation, which could also be secondary to monoclonal gammopathy of undetermined signifi...
-
Article
Open AccessDelayed diagnosis of acromegaly in a patient with focal segmental Glomerulosclerosis: a rare case report and literature review
Experimental studies have demonstrated that hypersecretion of growth hormone (GH) is associated with development of glomerular sclerosis. However, clinical case of such condition is very rare. Here we presente...
-
Article
Open AccessHereditary renal amyloidosis with a variant lysozyme p.Trp82Arg in a Chinese family: case report and literature review
Lysozyme amyloidosis is a rare hereditary systemic amyloidosis with amyloid deposits in various tissues leading to progressive organ failure. It has been mainly reported in developed countries since 1993. Here...
-
Article
Open AccessMembranoproliferative glomerulonephritis with deposition of monoclonal IgG evolved from polyclonal IgG: a case report with two consecutive renal biopsies
Proliferative glomerulonephritis with monoclonal Immunoglobulin (G) deposits (PGNMID) is a rare kind of MGRS with intact monoclonal IgG deposition. Seventy percent of PGNMID patients were negative for M-spike.
-
Article
Open AccessMercury-associated glomerulonephritis: a retrospective study of 35 cases in a single Chinese center
Long-term exposure of mercury may induce glomerulonephritis. Clinical and pathological features of mercury-associated glomerulonephritis are not fully clear. This study retrospectively analyzed 35 cases of mer...
-
Article
Immunological features and functional analysis of anti-CFH autoantibodies in patients with atypical hemolytic uremic syndrome
Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. Anti-complement factor H (CFH) antibodies were thought to participate in the pathogenesis of aHUS. The aim of this ...
-
Article
Open AccessMonoclonal light chain crystalline podocytopathy and tubulopathy associated with monoclonal gammopathy of renal significance: a case report and literature review
Monoclonal gammopathy of renal significance (MGRS) is a recently defined group of renal diseases caused by monoclonal immunoglobulin secreted by nonmalignant proliferative B cell or plasma cell. Monoclonal imm...
