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1,072 Result(s)
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Article
Open AccessIdentification of four TTN variants in three families with fetal akinesia deformation sequence
TTN is a complex gene with large genomic size and highly repetitive structure. Pathogenic variants in TTN have been reported to cause a range of skeletal muscle and cardiac disorders. Homozygous or compound heter...
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Open AccessImpact of baseline cardiovascular risk on the outcomes of intensive blood pressure intervention: a post hoc analysis of the China rural hypertension control project
The 2018/2023 ESC/ESH Guidelines underlined a gap how baseline cardiovascular disease (CVD) risk predicted blood pressure (BP) lowering benefits. Further, 2017 ACC/AHA Guideline and 2021 WHO Guideline recommen...
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Hierarchically theoretical calculation and 3D reconstruction simulation of effective thermal conductivity for MTMS-based silica aerogels
Compared with nanoscale aerogels, the thermal conductivity of MTMS silica aerogel (MSA) is relatively large due to its micron-sized pore size, which hinders its popularization in the field of thermal insulatio...
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Dual-terminal artificial synapse in two-dimensional CrSBr memristor for neuromorphic computing
Novel computing technologies that imitate the principles of biological neural systems may serve low power consumption with significant cognitive and learning advantages. The development of memristors with non-...
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Multiple visual items can be simultaneously compared with target templates in memory
When we search for something, we often rely on both what we see and what we remember. This process can be divided into three stages: selecting items, identifying those items, and comparing them with what we ar...
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Open AccessIntegrated analysis of the role of PR/SET domain 14 in gastric cancer
Gastric cancer is one of the most common tumors worldwide, and most patients are deprived of treatment options when diagnosed at advanced stages. PRDM14 has carcinogenic potential in breast and non-small cell ...
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A rigidity theorem for self-expanders
In this paper, we completely classify 3-dimensional complete self-expanders with constant squared norm S of the second fundamental form and constant $...
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A small landslide induced a large disaster prior to the heavy rainy season in **kouhe, Sichuan, China: characteristics, mechanism, and lessons
Small-scale landslides that occur at unexpected locations and seasons can cause severe losses of life and property. Unusually, the Shidang landslide occurred prior to the rainy season in **kouhe County, Sichu...
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Health risk of human exposure to microplastics: a review
Microplastics are emerging contaminants that have been detected recently in most environmental and biological systems, yet their health risk for humans has not been clearly summarized. Here we review human hea...
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Non-confluence of fractional stochastic differential equations driven by Lévy process
In this paper, we investigate a class of stochastic Riemann-Liouville type fractional differential equations driven by Lévy noise. By using Itô formula for the considered equation, we attempt to explore the no...
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Tackling visual and conceptual complexity of problem-oriented modeling of requirements
In the contemporary age of cyber-physical systems (CPS), where software governs the control, coordination, and management of physical objects to tackle real-world problems, engineering requirements for such sy...
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Effects of Continuous Crop** and Application of Bio-organic Fertilizers on Growth, Yield and Quality of Sugar Beet under Reduced Chemical Fertilizer Application
A major problem in the cultivation of sugar beet is continuous crop** cycle. A study was carried out in the 2019–2021 season at the Agriculture and Forestry Sciences of Ulanqab, Inner Mongolia, to assess the...
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Ecological transitions in **njiang, China: Unraveling the impact of climate change on vegetation dynamics (1990–2020)
For the past several decades, climate change has been driving vegetation dynamics in arid regions worldwide. This study investigates vegetation dynamics and their links to climate from 1990 to 2020 in **njiang...
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Open AccessDetermination of cinnamaldehyde, thymol and eugenol in essential oils by LC–MS/MS and antibacterial activity of them against bacteria
Plant essential oils contain many secondary metabolites, some of which can effectively inhibit the growth of pathogenic microorganisms, so it is a very promising antibacterial agent. In this study, a qualitati...
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How is about the flash drought events and their impacts on vegetation in Central Asia
A flash drought typically exhibits rapid development and high intensity, with significant impacts on societies and ecosystems. Central Asia (CA), a typical arid region, little attention has been paid to the ch...
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Open AccessIGF2BP3 promotes glutamine metabolism of endometriosis by interacting with UCA1 to enhances the mRNA stability of GLS1
Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) has been implicated in numerous inflammatory and cancerous conditions. However, its precise molecular mechanisms in endometriosis (EMs) remains un...
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Open AccessStructural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase
Membrane-bound styrene oxide isomerase (SOI) catalyses the Meinwald rearrangement—a Lewis-acid-catalysed isomerization of an epoxide to a carbonyl compound—and has been used in single and cascade reactions. Ho...
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Open AccessPublic Health and Children’s Subjective Well-Being
In recent years, the study of children's subjective well-being has garnered escalating global attention, with its research themes becoming increasingly diverse. However, this field still lacks a systematic rev...
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Open AccessMDM2: current research status and prospects of tumor treatment
Mousedouble minute 2 (MDM2) is one of the molecules activated by p53 and plays an important role in the regulation of p53. MDM2 is generally believed to function as a negative regulator of p53 by facilitating ...
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Interface-constrained catalytic hairpin assembly permits highly sensitive SERS signaling of miRNA
The rapid and precise monitoring of peripheral blood miRNA levels holds paramount importance for disease diagnosis and treatment monitoring. In this study, we propose an innovative research strategy that combi...