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Article
Open AccessData synchronization techniques and their impact on the prediction performance of automated recalibrated soft sensors in bioprocesses
Innovative soft sensor concepts can recalibrate automatically when the prediction performance decreases due to variations in raw materials, biological variability, and changes in process strategies. For automa...
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Article
Open AccessUltrasonic mode conversion for in-line foam structure measurement in highly aerated batters using machine learning
An ultrasonic-based method was developed to enable in-line measurements of foam structure parameters for highly aerated batters by mode conversion. Biscuit batters were foamed to different degrees (density: 36...
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Article
UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
Reversible modification of target proteins by ubiquitin and ubiquitin-like proteins (UBLs) is widely used by eukaryotic cells to control protein fate and cell behaviour1. UFM1 is a UBL that predominantly modifies...
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Article
Open AccessInfluence of dextrins and β-glucans on palate fullness and mouthfeel of beer
Palate fullness (PF) and mouthfeel are important sensory attributes influencing beer quality. The molar mass of starch (dextrins) and non-starch (β-glucans) polysaccharides may influence PF (pleasant) or mouthfee...
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Protocol
Modular Assembly of Mitochondrial β-Barrel Proteins
Mitochondrial β-barrel proteins fulfill crucial roles in the biogenesis and function of the cell organelle. They mediate the import and membrane insertion of proteins and transport of small metabolites and ion...
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Chapter
Digitale Arbeitswelten – Auswirkungen auf Wirtschaft und Bildungssystem
Nur wenig beschäftigt uns so sehr wie die Arbeit, der wir nachgehen. Der Beitrag beschreibt die Auswirkungen der Digitalisierung auf die Arbeit der Zukunft. Die künstliche Intelligenz hat an Leistungs- und Ler...
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Article
Open AccessThe cost-utility of an intervention for children and adolescents with a parent having a mental illness in the framework of the German health and social care system: a health economic evaluation of a randomized controlled trial
Children of families with a parent with a mental illness have an increased risk of develo** social and mental health problems resulting in decreased quality of life. Therefore, children and adolescents livin...
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Article
Open AccessCOX17 acetylation via MOF–KANSL complex promotes mitochondrial integrity and function
Reversible acetylation of mitochondrial proteins is a regulatory mechanism central to adaptive metabolic responses. Yet, how such functionally relevant protein acetylation is achieved remains unexplored. Here ...
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Article
Open AccessLAG3 in gastric cancer: it’s complicated
Lymphocyte activation gene 3 (LAG3) is thought to contribute to T cell exhaustion within the tumor microenvironment of solid tumors. This study aimed to analyze the spatial distribution of LAG3 + cells in rela...
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Article
TCA cycle deficiency in multiple sclerosis
Impaired tricarboxylic acid cycle and oxidative phosphorylation cause reduced energy content in neurons upon neuroinflammation and contribute to axonal degeneration in multiple sclerosis.
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Article
Open AccessQuantification methods of determining brewer’s and pharmaceutical yeast cell viability: accuracy and impact of nanoparticles
For industrial processes, a fast, precise, and reliable method of determining the physiological state of yeast cells, especially viability, is essential. However, an increasing number of processes use magnetic...
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Article
Open AccessEvolution of Alternaria toxins during the brewing process and the usability of optical sorting methods to reduce mycotoxin concentrations in beer
To assess the impact of black-colored grain on Alternaria mycotoxin concentrations in different stages of the brewing process, brewing experiments were conducted in a microscale brewhouse. Different mixtures of v...
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Article
Open AccessMolecular basis for recognition and deubiquitination of 40S ribosomes by Otu2
In actively translating 80S ribosomes the ribosomal protein eS7 of the 40S subunit is monoubiquitinated by the E3 ligase Not4 and deubiquitinated by Otu2 upon ribosomal subunit recycling. Despite its importanc...
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Article
Hepatozelluläres Karzinom
Das therapeutische Spektrum des hepatozellulären Karzinoms (HCC) bei Leberzirrhose hat sich im letzten Jahrzehnt erweitert und umfasst chirurgische, interventionelle und systemische Ansätze. Das Tumorstadium u...
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Article
Open AccessStructural basis for clearing of ribosome collisions by the RQT complex
Translation of aberrant messenger RNAs can cause stalling of ribosomes resulting in ribosomal collisions. Collided ribosomes are specifically recognized to initiate stress responses and quality control pathway...
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Article
Author Correction: A multipoint guidance mechanism for β-barrel folding on the SAM complex
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Article
A multipoint guidance mechanism for β-barrel folding on the SAM complex
Mitochondrial β-barrel proteins are essential for the transport of metabolites, ions and proteins. The sorting and assembly machinery (SAM) mediates their folding and membrane insertion. We report the cryo-ele...
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Article
Open AccessMitochondrial complexome reveals quality-control pathways of protein import
Mitochondria have crucial roles in cellular energetics, metabolism, signalling and quality control1–4. They contain around 1,000 different proteins that often assemble into complexes and supercomplexes such as re...
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Article
Open AccessThe mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase
The mitochondrial F1FO-ATP synthase produces the bulk of cellular ATP. The soluble F1 domain contains the catalytic head that is linked via the central stalk and the peripheral stalk to the membrane embedded roto...
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Protocol
Rapid Testing of Gene Function in Axonal Regeneration After Spinal Cord Injury Using Larval Zebrafish
Larval zebrafish show axonal regrowth over a complex spinal injury site and recovery of function within days after injury. Here we describe a simple protocol to disrupt gene function in this model using acute ...
