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Article
Open AccessMitochondrial complexome reveals quality-control pathways of protein import
Mitochondria have crucial roles in cellular energetics, metabolism, signalling and quality control1–4. They contain around 1,000 different proteins that often assemble into complexes and supercomplexes such as re...
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Article
Open AccessA slit-diaphragm-associated protein network for dynamic control of renal filtration
The filtration of blood in the kidney which is crucial for mammalian life is determined by the slit-diaphragm, a cell-cell junction between the foot processes of renal podocytes. The slit-diaphragm is thought ...
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Article
Open AccessThe two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes
Two-pore channels (TPCs) are localized in endo-lysosomal compartments and assumed to play an important role for vesicular fusion and endosomal trafficking. Recently, it has been shown that both TPC1 and 2 were...
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Article
Open AccessAMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neurotransmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled consti...
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Article
Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics
GABAB receptors are the most abundant inhibitory G protein–coupled receptors in the mammalian brain. Using high-resolution proteomics, the authors show that native GABAB receptors are macromolecular complexes wit...
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Article
Native GABAB receptors are heteromultimers with a family of auxiliary subunits
A proteomics study of GABAB receptors, the receptors for γ-aminobutyric acid, the main inhibitory neurotransmitter in the brain, throws new light on the origin of their functional diversity. Rather than being het...
