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Article
Open AccessCentral role of Tim17 in mitochondrial presequence protein translocation
The presequence translocase of the mitochondrial inner membrane (TIM23) represents the major route for the import of nuclear-encoded proteins into mitochondria1,2. About 60% of more than 1,000 different mitochond...
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Article
Author Correction: A multipoint guidance mechanism for β-barrel folding on the SAM complex
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Article
A multipoint guidance mechanism for β-barrel folding on the SAM complex
Mitochondrial β-barrel proteins are essential for the transport of metabolites, ions and proteins. The sorting and assembly machinery (SAM) mediates their folding and membrane insertion. We report the cryo-ele...
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Article
Mitochondrial sorting and assembly machinery operates by β-barrel switching
The mitochondrial outer membrane contains so-called β-barrel proteins, which allow communication between the cytosol and the mitochondrial interior1–3. Insertion of β-barrel proteins into the outer membrane is me...
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Article
Open AccessPb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells
The mechanisms of Pb(II) toxicity have been studied in human red blood cells using confocal microscopy, immunolabeling, fluorescence-activated cell sorting and atomic force microscopy. The process follows a se...
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Article
Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug
Edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) is an anti-tumour cell ether lipid with surface-active properties. Pure edelfosine can be dispersed in aqueous media in the form of micelles. One...