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Article
Open AccessCortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder
While epigenetic modifications have been implicated in ADHD through studies of peripheral tissue, to date there has been no examination of the epigenome of the brain in the disorder. To address this gap, we ma...
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Article
Open AccessPolygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort
A new era of human postmortem tissue research has emerged thanks to the development of ‘omics technologies that measure genes, proteins, and spatial parameters in unprecedented detail. Also newly possible is t...
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Article
Open AccessAntipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia
Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of differentially expressed genes. However, the extent to which these gene expression changes reflect antipsychotic drug (APD...
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Article
Map** the cortico-striatal transcriptome in attention deficit hyperactivity disorder
Despite advances in identifying rare and common genetic variants conferring risk for ADHD, the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a molecular mechanistic und...
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Article
Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains
Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-ranging domains encompassing multiple transcriptional units, including heritability loci for psychiatric traits, remains lar...
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Article
Open AccessDeep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders
Despite strong evidence of heritability and growing discovery of genetic markers for major mental illness, little is known about how gene expression in the brain differs across psychiatric diagnoses, or how kn...
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Article
Open AccessFunctional annotation of rare structural variation in the human brain
Structural variants (SVs) contribute to many disorders, yet, functionally annotating them remains a major challenge. Here, we integrate SVs with RNA-sequencing from human post-mortem brains to quantify their d...
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Article
Open AccessA chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons
Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of ...
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Article
Open AccessCommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder
Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic regions associated with disease risk, less is know...
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Article
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition
GABAergic mechanisms have been shown to contribute to cognitive aging in animal models, but there is currently limited in vivo evidence to support this relationship in humans. It is also unclear whether aging ...
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Article
Comparison of shoulder replacement to treat osteoarthritis secondary to instability surgery and primary osteoarthritis: a retrospective controlled study of patient outcomes
We hypothesized that osteoarthritis develo** after instability surgery is radiographically similar to primary arthritis and that arthroplasty provides comparable outcomes in patients with these two types of ...
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Article
Convergence of placenta biology and genetic risk for schizophrenia
Defining the environmental context in which genes enhance disease susceptibility can provide insight into the pathogenesis of complex disorders. We report that the intra-uterine environment modulates the assoc...
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Article
Effects of the BDNF Val66Met Polymorphism on White Matter Microstructure in Healthy Adults
The BDNF Val66Met polymorphism, a possible risk variant for mental disorders, is a potent modulator of neural plasticity in humans and has been linked to deficits in gray matter structure, function, and cognition...
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Article
Effect of Schizophrenia Risk-Associated Alleles in SREB2 (GPR85) on Functional MRI Phenotypes in Healthy Volunteers
Genetic variants in GPR85 (SREB2: rs56080411 and rs56039557) have been associated with risk for schizophrenia. Here, we test the hypothesis that these variants impact on brain function in normal subjects, meas...
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Article
Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia
The purpose of this study was to examine measures of anatomical connectivity between the thalamus and lateral prefrontal cortex (LPFC) in schizophrenia and to assess their functional implications. We measured ...
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Article
Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT
γ-Aminobutyric acid (GABA)-ergic transmission is critical for normal cortical function and is likely abnormal in a variety of neuropsychiatric disorders. We tested the in vivo effects of variations in two genes i...
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Chapter and Conference Paper
Comparison of EPI Distortion Correction Methods in Diffusion Tensor MRI Using a Novel Framework
Diffusion weighted images (DWIs) are commonly acquired with Echo-planar imaging (EPI). B0 inhomogeneities affect EPI by producing spatially nonlinear image distortions. Several strategies have been proposed to...
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Chapter and Conference Paper
In Vivo NMR Measures of NAA and the Neurobiology of Schizophrenia
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Article
Nicotine-Induced Dopamine Release in Primates Measured with [11C]Raclopride PET
Nicotine-induced dopamine (DA) release constitutes a pharmacological probe of the DA system that has potential use in patients with schizophrenia, who have abnormally elevated DA release after amphetamine admi...
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Article
Erratum: Comparison of Cognitive Peformances During a Placebo Period and an Atypical Antipsychotic Treatment Period in Schizophrenia: Critical Examination of Confounds
Correction to: Neuropsychopharmacology (2003) 28, 1491–1500. doi: 10.1038/sj.npp.1300216 Following publication of the above paper, the author has identified an error on page 1494. The correct statement should ...