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Article
Open AccessLipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders
Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages span...
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Article
Open AccessA chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons
Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of ...
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Article
Open AccessChromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia
Both heritability and environment contribute to risk for schizophrenia. However, the molecular mechanisms of interactions between genetic and non-genetic factors remain unclear. Epigenetic regulation of neuron...
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Article
Open AccessMetabolome signature of autism in the human prefrontal cortex
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in AS...
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Article
Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors
Notwithstanding the considerable advances in the treatment options for schizophrenia, the cognitive symptoms in particular are not receptive to antipsychotic treatment and considered one of the main predictors...
