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  1. No Access

    Article

    Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes

    Most studies of gene expression in the brains of individuals with schizophrenia have focused on cortical regions, but subcortical nuclei such as the striatum are prominently implicated in the disease, and curr...

    Kynon J. M. Benjamin, Qiang Chen, Andrew E. Jaffe, Joshua M. Stolz… in Nature Neuroscience (2022)

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    Article

    Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

    Schizophrenia polygenic risk is plausibly manifested by complex transcriptional dysregulation in the brain, involving networks of co-expressed and functionally related genes. The main purpose of this study was...

    Eugenia Radulescu, Andrew E. Jaffe, Richard E. Straub, Qiang Chen… in Molecular Psychiatry (2020)

  3. Article

    Effect of Schizophrenia Risk-Associated Alleles in SREB2 (GPR85) on Functional MRI Phenotypes in Healthy Volunteers

    Genetic variants in GPR85 (SREB2: rs56080411 and rs56039557) have been associated with risk for schizophrenia. Here, we test the hypothesis that these variants impact on brain function in normal subjects, meas...

    Eugenia Radulescu, Fabio Sambataro, Venkata S Mattay… in Neuropsychopharmacology (2013)

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  4. Article

    Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT

    γ-Aminobutyric acid (GABA)-ergic transmission is critical for normal cortical function and is likely abnormal in a variety of neuropsychiatric disorders. We tested the in vivo effects of variations in two genes i...

    Stefano Marenco, Antonina A Savostyanova… in Neuropsychopharmacology (2010)

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