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Article
Executive Function, Neural Circuitry, and Genetic Mechanisms in Schizophrenia
After decades of research aimed at elucidating the pathophysiology and etiology of schizophrenia, it has become increasingly apparent that it is an illness knowing few boundaries. Psychopathological manifestat...
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Article
Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour
Williams syndrome is a neurodevelopmental disorder with a prevalence of up to 1 in 7,500, caused by a hemizygous deletion of ∼1.6 megabases, containing ∼28 gen...
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Article
Neural correlates of genetically abnormal social cognition in Williams syndrome
Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using function...
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Article
Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-met...
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Article
Nicotine-Induced Dopamine Release in Primates Measured with [11C]Raclopride PET
Nicotine-induced dopamine (DA) release constitutes a pharmacological probe of the DA system that has potential use in patients with schizophrenia, who have abnormally elevated DA release after amphetamine admi...
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Article
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia
Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we measured presynaptic dopaminergic...
